HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

BI-9321

a selective antagonist of the NSD3-PWWP1 domain

Also Known As:

(4-(5-(7-fluoroquinolin-4-yl)-1-methyl-1H-imidazol-4-yl)-3,5-dimethylphenyl)methanamine

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - BI-9321: 2
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - BI-9321: 2

Experts

1.	Vedadi, Masoud: 2 articles (01/2022 - 01/2019)
2.	Byrum, Stephanie D: 1 article (01/2022)
3.	Cai, Ling: 1 article (01/2022)
4.	Edmondson, Rick D: 1 article (01/2022)
5.	Gibson, Elisa: 1 article (01/2022)
6.	Gong, Weida: 1 article (01/2022)
7.	Jin, Jian: 1 article (01/2022)
8.	Kaniskan, H Ümit: 1 article (01/2022)
9.	Li, Dongxu: 1 article (01/2022)
10.	Mackintosh, Samuel G: 1 article (01/2022)

Related Diseases

1.

Neoplasms (Cancer)

01/01/2022 - "Importantly, MS9715, but not BI-9321, effectively suppresses growth of NSD3-dependent hematological cancer cells. "
01/01/2019 - "To further elucidate the relevance of NSD3 in cancer biology, we developed a chemical probe, BI-9321, targeting the methyl-lysine binding site of the PWWP1 domain with sub-micromolar in vitro activity and cellular target engagement at 1 µM. "

Related Drugs and Biologics

1.	methyl-lysine