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SKLB-03220

Also Known As:

5'-Acrylamido-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-5-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2',4-dimethyl-(1,1'-biphenyl)-3-carboxamide

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Acrylamides: 12
    - SKLB-03220: 2
- Carboxylic Acids: 973
  - Acyclic Acids
    - Acrylates: 212
      - Acrylamides: 12
        SKLB-03220: 2

Related Diseases

1.	Neoplasms (Cancer) 05/18/2023 - "In addition to the anti-tumor activity of SKLB-03220 in a PA-1 xenograft model, immunohistochemistry results showed that SKLB-03220 markedly increased the expression of TIMP2 and decreased the expression of MMP9. " 01/01/2023 - "Furthermore, oral administration of SKLB-03220 significantly inhibited tumor growth in PA-1 xenograft model without obvious adverse effects. "
2.	Ovarian Neoplasms (Ovarian Cancer) 01/01/2023 - "Moreover, SKLB-03220 displayed noteworthy potency against ovarian cancer cell lines and continuously abolished H3K27me3 after washing out. "
3.	Neoplasm Metastasis (Metastasis) 05/18/2023 - "Taken together, these results indicate that the EZH2 covalent inhibitor SKLB-03220 inhibits metastasis of OC cells by upregulating TIMP2 and downregulating MMP9, and could thus serve as a therapeutic agent for OC."

Related Therapies and Procedures

1.	Oral Administration