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ASPER-29

Also Known As:

((2S)-2-benzamido-3-phenylpropyl) (2S)-2-((4-bromophenyl)sulfonylamino)-3-phenylpropanoate

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133

Experts

1.	Dong, Ruitong: 1 article (02/2022)
2.	Dong, Tianyi: 1 article (02/2022)
3.	Li, Yanchun: 1 article (02/2022)
4.	Liu, Dongyue: 1 article (02/2022)
5.	Ma, Enlong: 1 article (02/2022)
6.	Yuan, Lei: 1 article (02/2022)
7.	Zhao, Juanping: 1 article (02/2022)
8.	Zhao, Songkun: 1 article (02/2022)

Related Diseases

1.	Pancreatic Neoplasms (Pancreatic Cancer) 02/01/2022 - "Together, our results demonstrated that ASPER-29, as a novel inhibitor of CAT-L and CAT-S, possessed the evident ability to block the metastasis of pancreatic cancer cells." 02/01/2022 - "Additionally, the activity of both CAT-L and CAT-S was markedly inhibited in the lung and liver tissues of ASPER-29-administered mice compared with the mice in the model group, suggesting that the metastasis-blocking effect of ASPER-29 should be mediated via inhibition of the activity of CAT-L and CAT-S in pancreatic cancer cells. " 02/01/2022 - "H&E staining and immunohistochemistry assays of Ki67 and CEACAM6 proved that ASPER-29 treatment significantly blocked the metastasis of pancreatic cancer cells to lung and liver tissues. " 01/01/2023 - "Asperphenamate analog ASPER-29, which exhibits dual Cat L and S inhibitory potency, showed a definite antimetastatic effect on pancreatic cancer BxPC-3 and PANC-1 cells. " 02/01/2022 - "To develop a stronger antimetastatic agent, ASPER-29, a novel inhibitor of CATs designed by using the asperphenamate derivative BBP as a lead compound, was synthesized, and its therapeutic potential in pancreatic cancer metastasis was investigated in this study. "
2.	Neoplasm Metastasis (Metastasis) 02/01/2022 - "Together, our results demonstrated that ASPER-29, as a novel inhibitor of CAT-L and CAT-S, possessed the evident ability to block the metastasis of pancreatic cancer cells." 02/01/2022 - "Additionally, the activity of both CAT-L and CAT-S was markedly inhibited in the lung and liver tissues of ASPER-29-administered mice compared with the mice in the model group, suggesting that the metastasis-blocking effect of ASPER-29 should be mediated via inhibition of the activity of CAT-L and CAT-S in pancreatic cancer cells. " 02/01/2022 - "H&E staining and immunohistochemistry assays of Ki67 and CEACAM6 proved that ASPER-29 treatment significantly blocked the metastasis of pancreatic cancer cells to lung and liver tissues. " 02/01/2022 - "To develop a stronger antimetastatic agent, ASPER-29, a novel inhibitor of CATs designed by using the asperphenamate derivative BBP as a lead compound, was synthesized, and its therapeutic potential in pancreatic cancer metastasis was investigated in this study. " 02/01/2022 - "ASPER-29 suppresses the metastasis of pancreatic cancer cells by dual inhibition of cathepsin-L and cathepsin-S."

Related Drugs and Biologics

1.	asperphenamate
2.	4-boronic acid benzophenone
3.	Cathepsin L
4.	cathepsin S