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salviolone

Also Known As:

9-hydroxy-4,4,8-trimethyl-2,3-dihydro-1H-cyclohepta(a)naphthalen-10-one

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Naphthalenes: 18
        salviolone: 5
    - Alicyclic Hydrocarbons: 1
      - Cycloparaffins: 6
        Cycloheptanes
        salviolone: 5
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Naphthalenes: 18
    - salviolone: 5

Experts

1.	Campagnari, Rachele: 1 article (01/2022)
2.	Cardile, Alessia: 1 article (01/2022)
3.	Cerulli, Antonietta: 1 article (01/2022)
4.	Masullo, Milena: 1 article (01/2022)
5.	Menegazzi, Marta: 1 article (01/2022)
6.	Piacente, Sonia: 1 article (01/2022)
7.	Zanrè, Valentina: 1 article (01/2022)
8.	Chai, Yuna: 1 article (01/2022)
9.	Liu, Xiaoting: 1 article (01/2022)
10.	Lu, Yaoyao: 1 article (01/2022)

Related Diseases

1.	Uterine Cervical Neoplasms (Cancer of the Cervix) 11/01/2018 - "In this study the antiproliferative and anticancer effects of Salviolone were evaluated against HeLa cervical cancer cell line along with determining the anticancer mode of action. " 11/01/2018 - "Taken all together, it is concluded that Salviolone could prove to be an important lead molecule for the treatment of cervical cancer." 11/01/2018 - "Salviolone could also cause arrest of the HeLa cervical cancer cells in the G2/M phase of the cell cycle and suppress their ability to migrate and invade. " 11/01/2018 - "Inhibition of human cervical cancer cell growth by Salviolone is mediated via autophagy induction, cell migration and cell invasion suppression, G2/M cell cycle arrest and downregulation of Nf-kB/m-TOR/PI3K/AKT pathway."
2.	Diabetes Complications 01/01/2021 - "KEGG pathway enrichment analysis screened 156 signal pathways (P < 0.05), involving PI3K-Akt signal pathway, AGE-RAGE signal pathway in diabetes complications, MAPK signal pathway, HIF-1 signal pathway, IL-17 signal pathway, etc. Molecular docking results showed that quercetin, luteolin, kaempferol, tanshinone IIa, wogonin, naringenin, nobiletin, dihydrotanshinlactone, beta-sitosterol, and salviolone have good affinity with core target proteins IL6, PTGS2, MAPK1, MAPK3, and CGRP1. "
3.	Ovarian Neoplasms (Ovarian Cancer) 01/01/2022 - "The main active components of the Danshen-Guizhi drug pair in the treatment of ovarian cancer are salviolone, luteolin, β-sitosterol and tanshinone IIA. "
4.	Neoplasms (Cancer) 01/20/2022 - "Finally, salviolone and cryptotanshinone inhibit to a comparable extent some crucial malignancy features of A375 melanoma cells, such as colony formation in soft agar and metalloproteinase-2 activity. "
5.	Melanoma (Melanoma, Malignant) 01/20/2022 - "Likewise, salviolone has been shown to impair the viability of melanoma cells without affecting the growth of normal melanocytes. " 01/20/2022 - "Salviolone from Salvia miltiorrhiza Roots Impairs Cell Cycle Progression, Colony Formation, and Metalloproteinase-2 Activity in A375 Melanoma Cells: Involvement of P21(Cip1/Waf1) Expression and STAT3 Phosphorylation." 01/20/2022 - "In conclusion, it has been shown for the first time that salviolone, harboring a different molecular structure than tanshinone IIA and cryptotanshinone, exhibits a pleiotropic effect against melanoma by hampering cell cycle progression, STAT3 signaling, and malignant phenotype of A375 melanoma cells." 01/20/2022 - "Finally, salviolone and cryptotanshinone inhibit to a comparable extent some crucial malignancy features of A375 melanoma cells, such as colony formation in soft agar and metalloproteinase-2 activity. "

Related Drugs and Biologics

1.	tanshinone
2.	Luteolin
3.	gamma-sitosterol (beta-sitosterol)
4.	Cyclooxygenase 2 (Cyclooxygenase-2)
5.	Interleukin-17 (Interleukin 17)
6.	NF-kappa B (NF-kB)
7.	Interleukin-6 (Interleukin 6)
8.	Quercetin
9.	Proteins (Proteins, Gene)
10.	Metalloendopeptidases (Metalloendopeptidase)