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APX2039

Also Known As:

3-(3-((4-(6-fluoropyridin-2-yl)oxyphenyl)methyl)-1,2-oxazol-5-yl)pyridin-2-amine; APX-2039

Networked: 1 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Oxazoles: 89
      - APX2039: 1
  - Pyridines: 88
    - APX2039: 1

Related Diseases

1.	Cryptococcal Meningitis 12/20/2022 - "Here, we demonstrated the efficacy of APX2039, the second member of the gepix class, in rabbit and mouse models of cryptococcal meningitis. " 12/20/2022 - "Efficacy of APX2039 in a Rabbit Model of Cryptococcal Meningitis." 12/20/2022 - "These data support the further preclinical and clinical evaluation of APX2039 as a new oral fungicidal monotherapy for the treatment of CM. IMPORTANCE Cryptococcal meningitis (CM) is a fungal disease with significant global morbidity and mortality. "
2.	Mycoses (Diseases, Fungus) 12/20/2022 - "These data support the further preclinical and clinical evaluation of APX2039 as a new oral fungicidal monotherapy for the treatment of CM. IMPORTANCE Cryptococcal meningitis (CM) is a fungal disease with significant global morbidity and mortality. "
3.	Body Weight (Weight, Body) 12/20/2022 - "In the rabbit model of CM, the oral administration of APX2039 at 50 mg/kg of body weight twice a day (BID) resulted in a rapid decrease in the cerebrospinal fluid (CSF) fungal burden, and the burden was below the limit of detection by day 10 postinfection. "

Related Therapies and Procedures

1.	Oral Administration