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ML216

Also Known As:

1-(4-Fluoro-3-(trifluoromethyl)phenyl)-3-(5-(pyridin-4-yl)-1,3,4-thiadiazol-2-yl)urea

Networked: 3 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Urea: 15015
    - ML216: 3
- Sulfur Compounds: 278
  - Thiazoles: 392
    - Thiadiazoles: 99
      - ML216: 3
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Thiazoles: 392
      - Thiadiazoles: 99
        ML216: 3

Experts

1.	Du, Liqing: 1 article (12/2021)
2.	He, Ningning: 1 article (12/2021)
3.	Ji, Kaihua: 1 article (12/2021)
4.	Kong, Yangyang: 1 article (12/2021)
5.	Liu, Qiang: 1 article (12/2021)
6.	Liu, Yang: 1 article (12/2021)
7.	Sun, Hao: 1 article (12/2021)
8.	Sun, Xiaohui: 1 article (12/2021)
9.	Wang, Jinhan: 1 article (12/2021)
10.	Wang, Qin: 1 article (12/2021)

Related Diseases

1.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 12/01/2021 - "We aimed to investigate the radiosensitizing efficacy of the poly-ADP-ribose polymerase (PARP) inhibitor, olaparib, and the Bloom syndrome protein (BLM) helicase inhibitor, ML216, in non-small cell lung cancer (NSCLC) cells. "
2.	Idiopathic Pulmonary Fibrosis 12/29/2022 - "ML216 enhances pulmonary function by lowering the levels of senescence and fibrosis in both aged mice and a mouse model of bleomycin-induced idiopathic pulmonary fibrosis. "
3.	Neoplasms (Cancer) 12/01/2021 - "Mechanistically, the effects of ML216, olaparib, and radiation on cell and tumor proliferation, DNA damage, cell cycle, apoptosis, homologous recombination (HR) repair, and non-homologous end joining (NHEJ) repair activity were determined. "
4.	Lung Neoplasms (Lung Cancer) 12/01/2021 - "In addition to increases of double strand break (DSB) damage and decreases of Rad51 foci, olaparib combined with ML216 also increased pDNA-PKcs (S2056) foci, abrogated G2 cell cycle arrest, and induced apoptosis in A549 lung cancer after irradiation in vitro and in vivo (P < 0.05). "
5.	Fibrosis (Cirrhosis) 12/29/2022 - "ML216 enhances pulmonary function by lowering the levels of senescence and fibrosis in both aged mice and a mouse model of bleomycin-induced idiopathic pulmonary fibrosis. "

Related Drugs and Biologics

1.	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)
2.	Poly(ADP-ribose) Polymerase Inhibitors
3.	olaparib
4.	Bloom syndrome protein
5.	DNA Helicases
6.	Bleomycin (Blenoxane)
7.	lysyl- arginyl- alanyl- lysyl- alanyl- lysyl- threonyl- threonyl- lysyl- lysyl- arginine (PKCS)
8.	1,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)