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cough hypersensitivity syndrome

Also Known As:

sensory neuropathic cough

Networked: 11 relevant articles (3 outcomes, 3 trials/studies)

Relationship Network

Disease Context: Research Results

Respiratory Tract Diseases: 6015
- cough hypersensitivity syndrome: 11

Related Diseases

1.	Chronic Cough
2.	Hypersensitivity (Allergy)
3.	Inflammation (Inflammations)
4.	Cough

Experts

1.	Bastian, Robert W: 3 articles (10/2021 - 07/2006)
2.	Ahmad, Sumera R: 1 article (01/2022)
3.	Iyer, Vivek N: 1 article (01/2022)
4.	Hoesli, Rebecca C: 1 article (10/2021)
5.	Wajsberg, Benjamin: 1 article (10/2021)
6.	Wingo, Melissa L: 1 article (10/2021)
7.	Qiu, Zhongmin: 1 article (05/2020)
8.	Wang, Shengyuan: 1 article (05/2020)
9.	Xu, Xianghuai: 1 article (05/2020)
10.	Yu, Li: 1 article (05/2020)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to cough hypersensitivity syndrome:

1.	Gabapentin (Neurontin)FDA LinkGeneric 05/01/2023 - "In diagnoses of refractory chronic cough with uncertain etiology and a negative evaluation for life-threatening causes, cough hypersensitivity syndrome should be considered and managed with gabapentin or pregabalin and a trial of speech therapy." 01/01/2015 - "This study sought to: (1) quantify response rate and efficacy of amitriptyline, desipramine, and gabapentin in treating sensory neuropathic cough; and (2) describe an efficient treatment protocol. " 01/01/2015 - "Amitriptyline, desipramine, and gabapentin appear to vary in their effectiveness for individual cases of sensory neuropathic cough; across a whole cohort, symptom relief was similar in frequency and degree on any of the three medications. " 01/01/2015 - "Upon diagnosis of sensory neuropathic cough, each person was treated with either amitriptyline, desipramine, or gabapentin, titrating the dose upward to desired benefit or the dose limit. "
2.	Amitriptyline (Elavil)FDA LinkGeneric 07/01/2006 - "To describe our experience with chronic sensory neuropathic cough and its response to amitriptyline in a first group of patients. " 01/01/2015 - "This study sought to: (1) quantify response rate and efficacy of amitriptyline, desipramine, and gabapentin in treating sensory neuropathic cough; and (2) describe an efficient treatment protocol. " 01/01/2015 - "Amitriptyline, desipramine, and gabapentin appear to vary in their effectiveness for individual cases of sensory neuropathic cough; across a whole cohort, symptom relief was similar in frequency and degree on any of the three medications. " 01/01/2015 - "Upon diagnosis of sensory neuropathic cough, each person was treated with either amitriptyline, desipramine, or gabapentin, titrating the dose upward to desired benefit or the dose limit. "
3.	Desipramine (Pertofrane)FDA LinkGeneric 01/01/2015 - "This study sought to: (1) quantify response rate and efficacy of amitriptyline, desipramine, and gabapentin in treating sensory neuropathic cough; and (2) describe an efficient treatment protocol. " 01/01/2015 - "Amitriptyline, desipramine, and gabapentin appear to vary in their effectiveness for individual cases of sensory neuropathic cough; across a whole cohort, symptom relief was similar in frequency and degree on any of the three medications. " 01/01/2015 - "Upon diagnosis of sensory neuropathic cough, each person was treated with either amitriptyline, desipramine, or gabapentin, titrating the dose upward to desired benefit or the dose limit. "
4.	Neurotransmitter Agents (Neurotransmitter)IBA 08/01/2011 - "Neuromodulators for sensory neuropathic cough and new compounds to block transient receptor potential (TRP) receptors hold promise for chronic cough and upper airway hypersensitivity. "
5.	Capsaicin (Zostrix)FDA Link 10/01/2021 - "To evaluate a novel treatment for sensory neuropathic cough (SNC): topical capsaicin. " 10/01/2021 - "Topical Capsaicin for the Treatment of Sensory Neuropathic Cough."
6.	AcidsIBA 04/01/2011 - "However, it has become clear from studies on cough hypersensitivity syndrome that much reflux of importance in the airways has been missed, since it is either non- or weakly acid and gaseous in composition. "
7.	Pregabalin (Lyrica)FDA Link 05/01/2023 - "In diagnoses of refractory chronic cough with uncertain etiology and a negative evaluation for life-threatening causes, cough hypersensitivity syndrome should be considered and managed with gabapentin or pregabalin and a trial of speech therapy."
8.	Nerve Growth Factor (NGF)IBA 01/01/2017 - " the PNE neuronal model we observed both NGF and poly I:C mediated sensory neuronal hyperresponsiveness, representing potential neuro-inflammatory mechanisms associated with heightened nociceptive responses recognised in cough hypersensitivity syndrome."
9.	GABA Receptors (GABA Receptor)IBA 06/01/2015 - "NMDA and GABA receptors as potential targets in cough hypersensitivity syndrome."
10.	N-Methylaspartate (NMDA)IBA 06/01/2015 - "NMDA and GABA receptors as potential targets in cough hypersensitivity syndrome."

Therapies and Procedures

1.	Speech Therapy (Therapy, Speech) 05/01/2023 - "In diagnoses of refractory chronic cough with uncertain etiology and a negative evaluation for life-threatening causes, cough hypersensitivity syndrome should be considered and managed with gabapentin or pregabalin and a trial of speech therapy."
2.	Therapeutics 01/01/2022 - "The newly described paradigm and entity of cough hypersensitivity syndrome (CHS) becomes useful when the etiology of cough remains elusive or when the cough remains refractory despite appropriate therapy for underlying causes. "