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GST-HG131

HBV antigen inhibitor

Also Known As:

(7R)-7-tert-butyl-2-methoxy-3-(3-methoxypropoxy)-11-oxo-6,7-dihydropyrido(1,2-d)(1,4)benzoxazepine-10-carboxylic acid

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - GST-HG131: 2
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzoxepins: 1
      - GST-HG131: 2

Experts

1.	Chen, Shuhui: 1 article (01/2022)
2.	Ding, Charles: 1 article (01/2022)
3.	Ding, Yanhua: 1 article (01/2022)
4.	Gao, Lei: 1 article (01/2022)
5.	Hu, Yanbin: 1 article (01/2022)
6.	Li, Xiaojiao: 1 article (01/2022)
7.	Liu, Yusi: 1 article (01/2022)
8.	Lou, Jinfeng: 1 article (01/2022)
9.	Mao, John: 1 article (01/2022)
10.	Niu, Junqi: 1 article (01/2022)

Related Diseases

1.	Infections 01/01/2022 - "These findings imply GST-HG131 has potential as a therapeutic option for CHB infection. " 11/01/2022 - "Discovery and preclinical evaluations of GST-HG131, a novel HBV antigen inhibitor for the treatment of chronic hepatitis B infection."
2.	Chronic Hepatitis B 11/01/2022 - "Discovery and preclinical evaluations of GST-HG131, a novel HBV antigen inhibitor for the treatment of chronic hepatitis B infection."
3.	Nausea 01/01/2022 - "Single doses of GST-HG131 ≤ 300 mg and multiple doses of GST-HG131 ≤ 60 mg were generally safe and well tolerated; however, multiple dosing was stopped at GST-HG131 100 mg, as pre-defined stopping rules specified in the protocol were met (Grade II drug related AEs of nausea and dizziness in >50% of subjects). "
4.	Dizziness (Lightheadedness) 01/01/2022 - "Single doses of GST-HG131 ≤ 300 mg and multiple doses of GST-HG131 ≤ 60 mg were generally safe and well tolerated; however, multiple dosing was stopped at GST-HG131 100 mg, as pre-defined stopping rules specified in the protocol were met (Grade II drug related AEs of nausea and dizziness in >50% of subjects). "

Related Drugs and Biologics

1.	Antigens