3-chloro-5-hydroxybenzoic acid

A potent GPR81 agonist.

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

1.	Blochet, Camille: 1 article (01/2021)
2.	Buscemi, Lara: 1 article (01/2021)
3.	Hirt, Lorenz: 1 article (01/2021)
4.	Magistretti, Pierre J: 1 article (01/2021)
5.	Carruthers, Nicholas I: 1 article (08/2012)
6.	Dvorak, Curt A: 1 article (08/2012)
7.	Kuei, Chester: 1 article (08/2012)
8.	Liu, Changlu: 1 article (08/2012)
9.	Lovenberg, Timothy W: 1 article (08/2012)
10.	Shelton, Jonathan: 1 article (08/2012)

1.	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 01/01/2021 - "To test whether HCAR1 plays a role in lactate-induced neuroprotection, we injected the agonists 3-chloro-5-hydroxybenzoic acid and 3,5-dihydroxybenzoic acid into mice subjected to 30-min middle cerebral artery occlusion. "
2.	Obesity 08/09/2012 - "An examination of structurally similar arylhydroxy acids led to the identification of 3-chloro-5-hydroxybenzoic acid 2, a selective GPR81 agonist that exhibited favorable in vivo effects on lipolysis in a mouse model of obesity. "
3.	Fatigue 11/01/2022 - "We found that intracerebroventricular injection of either d-lactate (an enantiomer that could mediate activation of GPR81 as l-lactate) or a potent GPR81 agonist 3-chloro-5-hydroxybenzoic acid (CHBA), significantly decreased the swimming time to fatigue. "