rakicidins

11/26/2014 - "A hydrogenated derivative of rakicidin A, its ring-opened product, and two congeners with different alkyl chain lengths were tested for hypoxia-selective cytotoxicity. "
03/01/2011 - "Here, we describe Rakicidin A-induced cell death in hypoxia-adapted (HA)-CML cells with stem cell-like characteristics. "
03/01/2011 - "Rakicidin A effectively induces apoptosis in hypoxia adapted Bcr-Abl positive leukemic cells."
05/10/2018 - "In a highly metastatic pancreatic cancer cell line ASPC-1, compound 32g showed about 4 times higher potency (IC50 = 0.022 μM) than rakicidin A (IC50 = 0.082 μM) at hypoxia condition, and 12 folds of hypoxia selectivity (IC50 = 0.27 μM at nomoxia condition). "
03/01/2011 - "A previous report showed that Rakicidin A, a natural product produced by the Micromonospora strain, induced hypoxia-selective cytotoxicity in solid tumors. "

08/21/2023 - "Rakicidin B1 was isolated and purified from the culture broth of a marine Streptomyces sp. as a potent anti-cancer agent, and lately the compound and its derivatives have firstly been found to possess anti-Clostridium difficile (CD) activity but with high cytotoxicity. "
05/10/2018 - "More importantly, the tumor-initiating frequency was reduced by 19 folds after the treatment of 32g, which is better than that of rakicidin A (reduction of 4.7 folds)."
09/01/2010 - "Rakicidin D, an inhibitor of tumor cell invasion from marine-derived Streptomyces sp."
03/01/2011 - "A previous report showed that Rakicidin A, a natural product produced by the Micromonospora strain, induced hypoxia-selective cytotoxicity in solid tumors. "
12/28/2011 - "The rakicidins are cytotoxic lipopeptides with interesting cancer cell selectivities including HIF-1-independent hypoxia-selective cytotoxicity and anti-invasive activity. "

02/11/2016 - "Natural product rakicidin A induces cell death in TKI-resistant chronic myelogenous leukemia (CML) cells. "
02/11/2016 - "Structure-Activity Relationship Study of Rakicidins: Overcoming Chronic Myeloid Leukemia Resistance to Imatinib with 4-Methylester-Rakicidin A."
11/05/2014 - "Rakicidin A is a cyclic depsipeptide that has exhibited unique growth inhibitory activity against chronic myelogenous leukemia stem cells. "

05/10/2018 - "Syntheses and anti-pancreatic cancer activities of rakicidin A analogues."
05/10/2018 - "In a highly metastatic pancreatic cancer cell line ASPC-1, compound 32g showed about 4 times higher potency (IC50 = 0.022 μM) than rakicidin A (IC50 = 0.082 μM) at hypoxia condition, and 12 folds of hypoxia selectivity (IC50 = 0.27 μM at nomoxia condition). "