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Ibezapolstat

Also Known As:

ACX-362E

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Purines: 651
      - Purine Nucleosides: 360
        Ibezapolstat: 4
Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleosides: 6847
  - Purine Nucleosides: 360
    - Ibezapolstat: 4

Experts

1.	Silverman, Michael H: 2 articles (09/2022 - 01/2019)
2.	Begum, Khurshida: 1 article (09/2022)
3.	Dinh, An Q: 1 article (09/2022)
4.	Garey, Kevin W: 1 article (09/2022)
5.	Gonzales-Luna, Anne J: 1 article (09/2022)
6.	Hanson, Blake M: 1 article (09/2022)
7.	Hu, Chenlin: 1 article (09/2022)
8.	Jahangir Alam, M: 1 article (09/2022)
9.	Jo, Jinhee: 1 article (09/2022)
10.	Lancaster, Chris K: 1 article (09/2022)

Related Diseases

1.

Clostridium Infections

01/01/2022 - "Efficacy, Safety, Pharmacokinetics, and Microbiome Changes of Ibezapolstat in Adults with Clostridioides difficile Infection: A Phase 2a Multicenter Clinical Trial."
01/01/2022 - "Functional and Metagenomic Evaluation of Ibezapolstat for Early Evaluation of Anti-Recurrence Effects in Clostridioides difficile Infection."
01/01/2020 - "Ibezapolstat (ACX-362E) is the first DNA polymerase IIIC inhibitor undergoing clinical development for the oral treatment of Clostridioides difficile infection (CDI). "
01/01/2019 - "This review therefore examines the evolution of DNA pol IIIC inhibitors from the discovery of 6-(p-hydroxyphenylazo)uracil (HPUra) in the 1960s to the development of current first-in-class N7-substituted guanine drug candidate ACX-362E, now under clinical development for the treatment of Clostridioides difficile infection."

Related Drugs and Biologics

1.	Guanine
2.	DNA-Directed DNA Polymerase (Polymerases, DNA)
3.	DNA (Deoxyribonucleic Acid)
4.	6-(4-hydroxyphenylhydrazino)uracil