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TL8-506

Also Known As:

ethyl 2-amino-8-(3-cyanophenyl)-3H-1-benzazepine-4-carboxylate

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzazepines: 5
      - TL8-506: 1

Experts

1.	Bacac, Marina: 1 article (01/2022)
2.	Calabro, Samuele: 1 article (01/2022)
3.	De Silva, Duvini: 1 article (01/2022)
4.	Dummer, Reinhard: 1 article (01/2022)
5.	Gasser, Stephan: 1 article (01/2022)
6.	He, Mi: 1 article (01/2022)
7.	Hüsser, Tamara: 1 article (01/2022)
8.	Krümpelmann, Laura: 1 article (01/2022)
9.	Levesque, Mitchell P: 1 article (01/2022)
10.	Matos, Ines: 1 article (01/2022)

Related Diseases

1.

Neoplasms (Cancer)

01/01/2022 - "While most cDCs in human tumors display a non-activated phenotype, TL8-506 combinations drive human tumor cDCs towards an immunostimulatory phenotype associated with Th1 responses on stimulation. "
01/01/2022 - "Combinations of Toll-like receptor 8 agonist TL8-506 activate human tumor-derived dendritic cells."
01/01/2022 - "Furthermore, chemokines associated with CD8+ T cell recruitment were induced in tumor-derived cDCs in response to TL8-506 combinations. "

Related Drugs and Biologics

1.	Toll-Like Receptor 8
2.	Chemokines
3.	chenodeoxycholate sulfate conjugate (CDCS)