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(S)- 5- (4- hydroxy- 3,5- dimethyl- phenyl)- indan- 1- ol

Also Known As:

PaPE-1

Networked: 4 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Indenes: 4
        Indans: 7
        (S)-5-(4-hydroxy-3,5-dimethyl-phenyl)-indan-1-ol: 4
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Indenes: 4
    - Indans: 7
      - (S)-5-(4-hydroxy-3,5-dimethyl-phenyl)-indan-1-ol: 4

Experts

1.	Katzenellenbogen, Benita S: 2 articles (09/2021 - 11/2018)
2.	Katzenellenbogen, John A: 2 articles (09/2021 - 11/2018)
3.	Kim, Sung Hoon: 2 articles (09/2021 - 11/2018)
4.	Kajta, M: 1 article (12/2021)
5.	Pietrzak, B A: 1 article (12/2021)
6.	Przepiórska, K: 1 article (12/2021)
7.	Wnuk, A: 1 article (12/2021)
8.	Arredondo Eve, Alicia: 1 article (09/2021)
9.	Chen, Karen L: 1 article (09/2021)
10.	Liu, Yu-Jeh: 1 article (09/2021)

Related Diseases

1.	Stroke (Strokes) 11/01/2018 - "Thus, the selective activation of nonnuclear ER by PaPE-1 decreased stroke severity and improved functional recovery in mice without undesirable uterotrophic effects. "
2.	Obesity 09/23/2021 - "In this study, we have examined the effects of PaPE-1 on metabolic health, in particular, examining its effects on the liver transcriptome and on plasma metabolites in two different mouse models: diet-induced obesity (DIO) and leptin-deficient (ob/ob) mice. "
3.	Ischemia 12/01/2021 - "This is the first study showing that a 6-h delayed posttreatment with PaPE-1 inhibited hypoxia/ischemia-induced neuronal death, as indicated by neutral red uptake in mouse primary cell cultures in vitro. " 12/01/2021 - "Posttreatment Strategy Against Hypoxia and Ischemia Based on Selective Targeting of Nonnuclear Estrogen Receptors with PaPE-1."
4.	Hypoxia (Hypoxemia) 12/01/2021 - "This is the first study showing that a 6-h delayed posttreatment with PaPE-1 inhibited hypoxia/ischemia-induced neuronal death, as indicated by neutral red uptake in mouse primary cell cultures in vitro. " 12/01/2021 - "Posttreatment Strategy Against Hypoxia and Ischemia Based on Selective Targeting of Nonnuclear Estrogen Receptors with PaPE-1."
5.	Neoplasms (Cancer) 11/01/2018 - "PaPE-1 and similar molecules may warrant consideration as efficacious ER modulators providing neuroprotection without detrimental effects on the uterus or cancer risk." 09/23/2021 - "Overall, our findings support a beneficial metabolic role for PaPE-1 and suggest that PaPE-1 may protect postmenopausal women from fatty liver disease without increasing reproductive cancer risk."

Related Drugs and Biologics

1.	Leptin
2.	Neutral Red
3.	Estrogen Receptors
4.	Glutathione (Reduced Glutathione)
5.	Fatty Acids (Saturated Fatty Acids)
6.	Estradiol (Delestrogen)
7.	Collagen