SLMP53-2

01/01/2022 - "Mutant p53 reactivator SLMP53-2 hinders ultraviolet B radiation-induced skin carcinogenesis."

08/10/2019 - "By analysis of their anti-proliferative effect on a panel of p53-null NCI-H1299 tumor cells ectopically expressing highly prevalent mutp53, the compound SLMP53-2 was selected based on its potential reactivation of multiple structural mutp53. "

04/01/2021 - "By targeting p53, SLMP53-2 may counteract major features of melanoma aggressiveness."
04/01/2021 - "SLMP53-2 also exhibited antitumor activity in human melanoma xenograft mouse models by repressing cell proliferation and EMT while stimulating apoptosis. "
04/01/2021 - "Importantly, SLMP53-2 did not induce resistance in melanoma cells. "
04/01/2021 - "SLMP53-2 inhibited the growth of human melanoma cells in a p53-dependent manner through induction of cell cycle arrest and apoptosis. "
04/01/2021 - "Two- and three-dimensional cell cultures and xenograft mouse models were used to unveil the antitumor activity and the underlying molecular mechanism of SLMP53-2 in melanoma. "

01/01/2022 - "SLMP53-2 further suppressed UVB-induced inflammation by inhibiting the nuclear translocation and DNA-binding ability of NF-κB, and promoted the expression of key players involved in keratinocytes differentiation. "

08/10/2019 - "SLMP53-2 Restores Wild-Type-Like Function to Mutant p53 through Hsp70: Promising Activity in Hepatocellular Carcinoma."