dagrocorat

Also Known As:

(4bS,7R,8aR)-4b,5,6,7,8,8a,9,10-octahydro-7-hydroxy-N-(2-methyl-3-pyridinyl)-4b-(phenylmethyl)-7-(trifluoromethyl)-2-phenanthrenecarboxamide hydrochloride (1:1); (4bS,7R,8aR)-4b-benzyl-7-hydroxy-n-(2-methylpyridin-3-yl)-7-(trifluoromethyl)-4b,5,6,7,8,8a,9,10-octahydrophenanthrene-2-carboxamide; PF 00251802; PF-00251802; PF-0251802; PF-0251802 hydrochloride; PF-802; PF00251802; dagrocorat hydrochloride

Networked: 3 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Tammara, Brinda: 3 articles (01/2018 - 12/2016)
2.	Checchio, Tina: 1 article (01/2018)
3.	Eng, Heather: 1 article (01/2018)
4.	Fleishaker, Dona: 1 article (01/2018)
5.	McFadyen, Lynn: 1 article (01/2018)
6.	Mukherjee, Arnab: 1 article (01/2018)
7.	Ripp, Sharon L: 1 article (01/2018)
8.	Stock, Thomas: 1 article (01/2018)
9.	Weatherley, Barry: 1 article (01/2018)
10.	Hey-Hadavi, Judith: 1 article (12/2016)

Related Diseases

1.	Rheumatoid Arthritis 01/01/2018 - "These findings support the further development of PF-00251802 and PF-04171327 as potential treatments for patients with rheumatoid arthritis (NCT00987038)." 01/01/2018 - "The prodrug fosdagrocorat (PF-04171327), with active DAGR metabolite PF-00251802 (Metabolite-1), is postulated to show superior efficacy over placebo and prednisone in patients with moderate to severe rheumatoid arthritis (RA). " 12/01/2016 - "Fosdagrocorat (PF-04171327) is a pro-drug form of PF-00251802, a dissociated agonist of the glucocorticoid receptor, under investigation for the treatment of rheumatoid arthritis. "
2.	Body Weight (Weight, Body) 12/01/2016 - "Subjects were aged 18 - 55 years; body mass index 17.5 - 30.5 kg/m2; total body weight > 45 kg. Following single doses of fosdagrocorat, the PK of PF-00251802 and its metabolite PF-04015475 were similar between Japanese (PF-00251802: mean area under the curve (AUC)inf (range across doses), 791 - 3,460 ng×h/mL; individual half-life (t1/2) 14.1 - 28.9 hours; PF-04015475: mean AUCinf, 395 - 1,740 ng×h/mL; individual t1/2 21.6 - 40.3 hours) and Western (PF-00251802: mean AUCinf, 750 - 4,150 ng×h/mL; individual t1/2 17.7 - 40.4 hours; PF-04015475: mean AUCinf, 394 - 2,160 ng×h/mL; individual t1/2 24.5 - 63.7 hours) subjects. "

Related Drugs and Biologics

1.	fosdagrocorat
2.	Prodrugs
3.	Prednisone (Sone)
4.	dagrocorat
5.	Glucocorticoid Receptors (Glucocorticoid Receptor)