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IMP-1088

Also Known As:

1-(5-(3,4-difluoro-2-(2-(1,3,5-trimethylpyrazol-4-yl)ethoxy)phenyl)-1-methylindazol-3-yl)-N,N-dimethylmethanamine

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrazoles: 61
      - Indazoles: 179
        IMP-1088: 3
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indazoles: 179
      - IMP-1088: 3

Experts

1.	Agoni, Clement: 1 article (02/2022)
2.	Enslin, Gill: 1 article (02/2022)
3.	Kwofie, Samuel K: 1 article (02/2022)
4.	Salifu, Elliasu Y: 1 article (02/2022)
5.	Soliman, Mahmoud E: 1 article (02/2022)
6.	Asfor, Amin S: 1 article (01/2018)
7.	Bell, Andrew S: 1 article (01/2018)
8.	Brannigan, James A: 1 article (01/2018)
9.	Guedán, Anabel: 1 article (01/2018)
10.	Hopkins-Navratilova, Iva: 1 article (01/2018)

Related Diseases

1.	Infections 10/01/2022 - "Given the significant genetic identity between VACV, monkeypox virus and variola virus L1 homologs, our data provides a basis for further investigating the role of N-myristoylation in poxviral infections as well as the potential of selective NMT inhibitors like IMP-1088 as broad-spectrum poxvirus inhibitors." 10/01/2022 - "Treatment with NMT inhibitor IMP-1088 potently abrogated VACV infection, while VACV gene expression, DNA replication, morphogenesis and EV formation remained unaffected. " 10/01/2022 - "Here, we examine the importance of N-myristoylation during vaccinia virus (VACV) infection in primate cells and demonstrate the anti-poxviral effects of IMP-1088. " 01/01/2018 - "We show that inhibition of the co-translational myristoylation of a specific virus-encoded protein (VP0) by IMP-1088 potently blocks a key step in viral capsid assembly, to deliver a low nanomolar antiviral activity against multiple RV strains, poliovirus and foot and-mouth disease virus, and protection of cells against virus-induced killing, highlighting the potential of host myristoylation as a drug target in picornaviral infections."
2.	Common Cold 02/01/2022 - "Dual-Inhibition of Human N-Myristoyltransferase Subtypes Halts Common Cold Pathogenesis: Atomistic Perspectives from the Case of IMP-1088."

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Antiviral Agents (Antivirals)
3.	glycylpeptide N-tetradecanoyltransferase