Docosahexaenoyl difluorodeoxycytidine

Also Known As:

4-(N)-Docosahexaenoyl 2', 2'-difluorodeoxycytidine; 4-amino-1-((2S,4S,5R)-2-docosa-2,4,6,8,10,12-hexaenoyl-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl)-5,6-difluoropyrimidin-2-one; DHA-dFdC

Networked: 5 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Docosahexaenoyl difluorodeoxycytidine: 5
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Docosahexaenoyl difluorodeoxycytidine: 5

Experts

1.	Cui, Zhengrong: 5 articles (01/2022 - 01/2016)
2.	Valdes, Solange A: 3 articles (01/2022 - 10/2019)
3.	Hursting, Stephen D: 2 articles (01/2022 - 01/2016)
4.	Alzhrani, Riyad F: 2 articles (01/2020 - 10/2019)
5.	Lansakara-P, Dharmika S P: 2 articles (01/2020 - 10/2019)
6.	Naguib, Youssef W: 2 articles (01/2017 - 01/2016)
7.	Valdes, Solange: 2 articles (01/2017 - 01/2016)
8.	Colemam, Michael F: 1 article (01/2022)
9.	Hufnagel, Stephanie: 1 article (01/2022)
10.	Liu, Kristyn A: 1 article (01/2022)

Related Diseases

1.	Leukemia 01/01/2017 - "At or below its RD-MTD, DHA-dFdC is effective against leukemia in a mouse model." 01/01/2017 - "This study was designed to test the short-term toxicity of DHA-dFdC in a mouse model and its efficacy in a mouse model of leukemia at or below its repeat-dose maximum tolerated dose (RD-MTD). " 01/01/2017 - "Finally, DHA-dFdC was i.v. injected into DBA/2 mice with syngeneic L1210 mouse leukemia cells to evaluate its efficacy at or below RD-MTD. " 01/01/2016 - "NCI-60 DTP Human Tumor Cell Line Screening revealed that DHA-dFdC has potent and broad-spectrum antitumor activity, especially in leukemia, renal, and central nervous system cancer cell lines. "
2.	Pancreatic Neoplasms (Pancreatic Cancer) 01/01/2022 - "4-(N)-Docosahexaenoyl 2', 2'-difluorodeoxycytidine induces immunogenic cell death in colon and pancreatic carcinoma models as a single agent." 01/01/2016 - "In human and murine pancreatic cancer cell lines, the IC50 value of DHA-dFdC was up to 10(5)-fold lower than that of dFdC. " 01/01/2022 - "In the present study, DHA-dFdC's ability to induce immunogenic cell death (ICD) was tested using CT26 mouse colorectal cancer cells, an established cell line commonly used for identifying ICD inducers, as well as Panc-02 mouse pancreatic cancer cells. " 01/01/2022 - "RNA sequencing experiments were conducted on PANC-1 human pancreatic cancer cells treated with DHA-dFdC, dFdC, or vehicle control in vitro. "
3.	Colorectal Neoplasms (Colorectal Cancer) 01/01/2022 - "In the present study, DHA-dFdC's ability to induce immunogenic cell death (ICD) was tested using CT26 mouse colorectal cancer cells, an established cell line commonly used for identifying ICD inducers, as well as Panc-02 mouse pancreatic cancer cells. "
4.	Neoplasms (Cancer) 10/30/2019 - "In addition, histology evaluation revealed a high level of apoptosis and tumor encapsulation in tumors in mice treated with DHA-dFdC-SLNs. " 10/30/2019 - "DHA-dFdC-SLNs also showed an increased cytotoxicity against certain tumor cells than DHA-dFdC. " 01/01/2016 - "DHA-dFdC is a promising compound for the potential treatment of cancers in organs such as the pancreas. " 01/01/2016 - "DHA-dFdC also significantly inhibited the growth of Panc-1 tumors orthotopically implanted in the pancreas of nude mice, whereas the molar equivalent dose of dFdC alone did not show any significant activity. " 01/01/2016 - "In nude mice with subcutaneously implanted human Panc-1 pancreatic tumors, the antitumor activity of DHA-dFdC was significantly stronger than the molar equivalent of dFdC alone, DHA alone, or the physical mixture of them (1:1, molar ratio). "
5.	Melanoma (Melanoma, Malignant) 10/30/2019 - "In mice bearing B16-F10 murine melanoma, DHA-dFdC-SLNs were significantly more effective than DHA-dFdC in controlling the tumor growth. " 01/22/2020 - "Finally, in mice with pre-establish B16-F10 murine melanoma, oral DHA-dFdC-SLNs increased their survival significantly, as compared with oral administration of the DHA-dFdC solution. "

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Related Therapies and Procedures

1.	Therapeutics
2.	Oral Administration