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ICF05016

Also Known As:

3((bis(2-chloroethyl)amino)((1-methyl-2-nitro-1H-imidazol-5-yl)methoxy)phosphoryl)amino)-N,N,N-trimethylpropane-1-aminium iodide

Networked: 2 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - ICF05016: 2

Experts

1.	Chezal, Jean-Michel: 2 articles (01/2021 - 01/2020)
2.	Maubert, Elise: 2 articles (01/2021 - 01/2020)
3.	Miot-Noirault, Elisabeth: 2 articles (01/2021 - 01/2020)
4.	Voissière, Aurélien: 2 articles (01/2021 - 01/2020)
5.	Weber, Valérie: 2 articles (01/2021 - 01/2020)
6.	Chautard, Emmanuel: 1 article (01/2021)
7.	Dedieu, Véronique: 1 article (01/2021)
8.	Degoul, Françoise: 1 article (01/2021)
9.	Gérard, Yvain: 1 article (01/2021)
10.	Canitrot, Damien: 1 article (01/2020)

Related Diseases

1.	Hypoxia (Hypoxemia) 01/01/2021 - "Nevertheless, in previous preclinical studies our lab demonstrated the potential of the hypoxia-activated prodrug (HAP) ICF05016 on EMC murine model inoculated with the H-EMC-SS human cell line. " 01/01/2021 - "Relevance of the combination of external beam radiotherapy with the hypoxia-activated prodrug ICF05016 in an experimental model of extraskeletal myxoid chondrosarcoma." 01/01/2020 - "In a previous work, ICF05016 was identified as efficient proteoglycan-targeting hypoxia-activated prodrug in a human extraskeletal myxoid chondrosarcoma model in mice and a first study of the structure-activity relationship of the QA function and the alkyl linker length was conducted. "
2.	Extraskeletal Myxoid Chondrosarcoma 01/01/2021 - "Relevance of the combination of external beam radiotherapy with the hypoxia-activated prodrug ICF05016 in an experimental model of extraskeletal myxoid chondrosarcoma." 01/01/2020 - "In a previous work, ICF05016 was identified as efficient proteoglycan-targeting hypoxia-activated prodrug in a human extraskeletal myxoid chondrosarcoma model in mice and a first study of the structure-activity relationship of the QA function and the alkyl linker length was conducted. "

Related Drugs and Biologics

1.	Prodrugs
2.	Proteoglycans (Proteoglycan)

Related Therapies and Procedures

1.	Radiotherapy