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IQ9 indolequinone

Also Known As:

IQ9

Networked: 1 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Quinones: 434
  - Indolequinones: 12
    - IQ9 indolequinone: 1
Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - Indolequinones: 12
        IQ9 indolequinone: 1

Experts

1.	Abdullah, Nurul A: 1 article (10/2021)
2.	Inman, Martyn: 1 article (10/2021)
3.	Martin, Stewart G: 1 article (10/2021)
4.	Moody, Christopher J: 1 article (10/2021)
5.	Storr, Sarah J: 1 article (10/2021)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 10/01/2021 - "The present study evaluates, using in vitro breast cancer models, the efficacy of a novel indolequinone compound (IQ9) as a single agent and in combination with ionising radiation using a variety of endpoint assays including cell proliferation, clonogenic survival, enzyme activity, and western blotting. " 10/01/2021 - "Results show that treatment with IQ9 significantly inhibited thioredoxin reductase activity, and inhibited cell growth and colony formation of breast cancer cells with IC50 values in the low micromolar ranges. "
2.	Triple Negative Breast Neoplasms 10/01/2021 - "IQ9 upregulated protein expression of thioredoxin reductase in luminal but not in triple-negative breast cancer cells which may explain the observed differential radiosensitisation. "

Related Drugs and Biologics

1.	Enzymes
2.	Thioredoxin-Disulfide Reductase
3.	Proteins (Proteins, Gene)
4.	Phenobarbital (Luminal)