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APR002

toll-like receptor 7 agonist

Also Known As:

APR 002; APR-002

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- APR002: 1

Experts

1.	Corpuz, Manny: 1 article (10/2019)
2.	Huang, Xu: 1 article (10/2019)
3.	Kallakury, Bhaskar V: 1 article (10/2019)
4.	Korolowizc, Kyle E: 1 article (10/2019)
5.	Li, Bin: 1 article (10/2019)
6.	Menne, Stephan: 1 article (10/2019)
7.	Miller, Andrew T: 1 article (10/2019)
8.	Plouffe, David M: 1 article (10/2019)
9.	Rodrigo, Evelyn: 1 article (10/2019)
10.	Suresh, Manasa: 1 article (10/2019)

Related Diseases

1.	Chronic Hepatitis B 10/01/2019 - "In an effort to increase the therapeutic window of TLR7 agonists to treat chronic hepatitis B (CHB), we developed an oral TLR7 agonist, APR002, designed to act locally in the gastrointestinal tract and liver, thus minimizing systemic exposure and improving tolerability. "
2.	Infections 10/01/2019 - "Conclusion: APR002 is a novel TLR7 agonist exhibiting a distinct PK/PD profile that in combination with ETV can safely attain a functional cure in woodchucks with chronic WHV infection. "
3.	Persistent Infection 10/01/2019 - "While APR002 and ETV single agents did not elicit sustained viral control, combination therapy resulted in durable immune-mediated suppression of the chronic infection. "

Related Therapies and Procedures

1.	Therapeutics