JHU395

glutamine antagonist

Also Known As:

isopropyl(2S)-6-diazo-5-oxo-2-(((phenyl(pivaloyloxy)methoxy)carbonyl)amino)hexanoate; propan-2-yl (2S)-6-diazo-2-((2,2-dimethylpropanoyloxy(phenyl)methoxy)carbonylamino)-5-oxohexanoate

Networked: 3 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Acyclic Acids
    - Caproates: 7
      - JHU395: 3
Lipids: 114793
- Fatty Acids: 27405
  - Volatile Fatty Acids: 3052
    - Caproates: 7
      - JHU395: 3

Experts

1.	Alt, Jesse: 2 articles (01/2021 - 01/2020)
2.	Rais, Rana: 2 articles (01/2021 - 01/2020)
3.	Slusher, Barbara S: 2 articles (01/2021 - 01/2020)
4.	Eberhart, Charles G: 1 article (01/2021)
5.	Maxwell, Micah J: 1 article (01/2021)
6.	Pham, Khoa: 1 article (01/2021)
7.	Raabe, Eric H: 1 article (01/2021)
8.	Sweeney, Heather: 1 article (01/2021)
9.	Aguilar, Joanna Marie H: 1 article (01/2020)
10.	Blakeley, Jaishri O: 1 article (01/2020)

Related Diseases

1.	Neurofibrosarcoma (MPNST) 12/01/2023 - "When combined with JHU395, Pro-905 enhanced the colony formation inhibitory potency of JHU395 in human MPNST cells and augmented the antitumor efficacy of JHU395 in mice. " 01/01/2020 - "In vivo, orally administered JHU395 delivered active GA to tumors with over 2-fold higher tumor-to-plasma exposure, and significantly inhibited tumor growth in a murine flank MPNST model without observed toxicity. " 12/01/2023 - "JHU395 inhibits de novo purine synthesis in human MPNST cells and murine tumors with partial decreases in purine monophosphates. " 12/01/2023 - "Previously, we found that the glutamine amidotransferase inhibitor JHU395 partially impeded tumor growth in preclinical models of MPNST. " 01/01/2020 - "The Novel Glutamine Antagonist Prodrug JHU395 Has Antitumor Activity in Malignant Peripheral Nerve Sheath Tumor."
2.	Neoplasms (Cancer) 01/01/2020 - "In vivo, orally administered JHU395 delivered active GA to tumors with over 2-fold higher tumor-to-plasma exposure, and significantly inhibited tumor growth in a murine flank MPNST model without observed toxicity. " 12/01/2023 - "JHU395 inhibits de novo purine synthesis in human MPNST cells and murine tumors with partial decreases in purine monophosphates. " 12/01/2023 - "Previously, we found that the glutamine amidotransferase inhibitor JHU395 partially impeded tumor growth in preclinical models of MPNST. "
3.	Sarcoma (Soft Tissue Sarcoma) 01/01/2020 - "Glutamine metabolism and the therapeutic potential of glutamine antagonists (GA), however, are incompletely understood in malignant peripheral nerve sheath tumor (MPNST), an aggressive soft tissue sarcoma observed in patients with neurofibromatosis type I. We investigated glutamine dependence of MPNST using JHU395, a novel orally bioavailable GA prodrug designed to circulate inert in plasma, but permeate and release active GA within target tissues. "
4.	Neurofibromatosis 1 (Neurofibromatosis Type I) 01/01/2020 - "Glutamine metabolism and the therapeutic potential of glutamine antagonists (GA), however, are incompletely understood in malignant peripheral nerve sheath tumor (MPNST), an aggressive soft tissue sarcoma observed in patients with neurofibromatosis type I. We investigated glutamine dependence of MPNST using JHU395, a novel orally bioavailable GA prodrug designed to circulate inert in plasma, but permeate and release active GA within target tissues. "
5.	Medulloblastoma 01/01/2021 - "Treatment of mice bearing orthotopic xenografts of human MYC-amplified medulloblastoma with JHU395 increased median survival from 26 to 45 days compared with vehicle control mice (p < 0.001 by log-rank test). " 01/01/2021 - "JHU395 treatment caused decreased growth and increased apoptosis in multiple human high-MYC medulloblastoma cell lines at lower concentrations than DON. " 01/01/2021 - "We hypothesized that JHU395 would have superior cell penetration compared with DON and would effectively and more potently kill MYC-expressing medulloblastoma. " 01/01/2021 - "Novel Glutamine Antagonist JHU395 Suppresses MYC-Driven Medulloblastoma Growth and Induces Apoptosis."

Related Drugs and Biologics

1.	Glutamine (L-Glutamine)
2.	Prodrugs
3.	purine