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poyendarone

deuterated analogue of dronedarone

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzofurans: 26
      - Amiodarone: 5571
        Dronedarone: 409
        poyendarone: 2

Experts

1.	Chan, Eric Chun Yong: 2 articles (04/2022 - 01/2021)
2.	Venkatesan, Gopalakrishnan: 2 articles (04/2022 - 01/2021)
3.	Lim, Royden Yu Ren: 1 article (04/2022)
4.	Tang, Lloyd Wei Tat: 1 article (04/2022)
5.	Goto, Ai: 1 article (01/2021)
6.	Hagiwara-Nagasawa, Mihoko: 1 article (01/2021)
7.	Izumi-Nakaseko, Hiroko: 1 article (01/2021)
8.	Kambayashi, Ryuichi: 1 article (01/2021)
9.	Matsumoto, Akio: 1 article (01/2021)
10.	Nunoi, Yoshio: 1 article (01/2021)

Related Diseases

1.	Mitochondrial Diseases (Mitochondrial Disease) 04/01/2022 - "A comparison of dronedarone and its in-house synthesized deuterated analogue (termed poyendarone) demonstrated that deuteration could attenuate its in vitro toxicity in HepG2 cells by modulating the extent of mitochondrial dysfunction, reducing the dissipation of mitochondrial membrane potential, and evoking a distinct apoptotic kinetic signature. "
2.	Heart Failure 01/01/2021 - "Poyendarone, a deuterated analogue of dronedarone, is expected to reduce the onset of cardiovascular adverse events of dronedarone, including congestive heart failure and excessive QT-interval prolongation. "
3.	Atrial Fibrillation 01/01/2021 - "Since information is still lacking on the anti-atrial fibrillatory property of poyendarone, we assessed it along with effects on the inter-atrial conduction time (IACT) and atrial effective refractory period (AERP) using the canine paroxysmal atrial fibrillation model. " 01/01/2021 - "Poyendarone shortened duration of burst pacing-induced atrial fibrillation, whereas such abbreviation was not observed by dronedarone. " 01/01/2021 - "An exploratory analysis of effects of poyendarone, a deuterated analogue of dronedarone, on the canine model of paroxysmal atrial fibrillation."

Related Drugs and Biologics

1.	Dronedarone