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T2AA

small molecule PIP‑box inhibitor

Also Known As:

PIP-box inhibitor T2AA

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenols: 677
        T2AA: 3

Experts

1.	Chen, Yaomin: 1 article (10/2021)
2.	Huang, Xiumei: 1 article (10/2021)
3.	Jiang, Lingxiang: 1 article (10/2021)
4.	Lu, Tao: 1 article (10/2021)
5.	Mendonca, Marc S: 1 article (10/2021)
6.	Su, Xiaolin: 1 article (10/2021)
7.	Wang, Jiangwei: 1 article (10/2021)
8.	Benarafa, Charaf: 1 article (11/2019)
9.	Burgener, Sabrina Sofia: 1 article (11/2019)
10.	Candalh, Céline: 1 article (11/2019)

Related Diseases

1.	Necrosis 10/28/2021 - "In this study, we found that compared to monotherapy, a nontoxic dose of the T2AA synergized with a sublethal dose of β-lapachone in an NQO1-dependent manner and that combination therapy prevented DNA repair, increased double-strand break (DSB) formation and promoted programmed necrosis and G1 phase cell cycle arrest. "
2.	Neoplasms (Cancer) 04/20/2012 - "T2AA inhibited growth of cancer cells with induction of early apoptosis. " 10/28/2021 - "To overcome this side effect and expand the therapeutic utility of β-lapachone, we demonstrate the effects of a novel combination therapy including β-lapachone and the proliferating cell nuclear antigen (PCNA) inhibitor T2 amino alcohol (T2AA) on various NQO1+ cancer cells. "
3.	Inflammation (Inflammations) 11/04/2019 - "Furthermore, T2AA provided a therapeutic benefit in mice during trinitro-benzene-sulfonic acid (TNBS)-induced colitis by decreasing oxidative stress, accelerating mucosal repair, and promoting the resolution of inflammation. "
4.	Colitis 11/04/2019 - "Furthermore, T2AA provided a therapeutic benefit in mice during trinitro-benzene-sulfonic acid (TNBS)-induced colitis by decreasing oxidative stress, accelerating mucosal repair, and promoting the resolution of inflammation. "

Related Drugs and Biologics

1.	beta-lapachone
2.	1,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)
3.	Proliferating Cell Nuclear Antigen (PCNA)
4.	Sulfonic Acids
5.	Benzene (Benzole)

Related Therapies and Procedures

1.	Therapeutics