S55746

targets BCL-2

Also Known As:

N-(4-hydroxyphenyl)-3-(6-((3S)-3-(morpholin-4-ylmethyl)-3,4-dihydro-1H-isoquinoline-2-carbonyl)-1,3-benzodioxol-5-yl)-N-phenyl-5,6,7,8-tetrahydroindolizine-1-carboxamide

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Oxazines: 9
    - Morpholines: 6
      - S55746: 3
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Isoquinolines: 34
      - S55746: 3
    - Indolizines: 3
      - S55746: 3

Experts

1.	Claperon, Audrey: 2 articles (01/2019 - 04/2018)
2.	Colland, Frédéric: 2 articles (01/2019 - 04/2018)
3.	Geneste, Olivier: 2 articles (01/2019 - 04/2018)
4.	Kraus-Berthier, Laurence: 2 articles (01/2019 - 04/2018)
5.	Morris, Erick: 2 articles (01/2019 - 04/2018)
6.	Rocchetti, Francesca: 2 articles (01/2019 - 04/2018)
7.	Wang, Youzhen: 2 articles (01/2019 - 04/2018)
8.	Chanrion, Maia: 1 article (01/2019)
9.	Ghiurau, Corina: 1 article (01/2019)
10.	Halilovic, Ensar: 1 article (01/2019)

Related Diseases

1.	Mantle-Cell Lymphoma (Lymphoma, Mantle Cell) 04/13/2018 - "Ex vivo, S55746 induces apoptosis in the low nanomolar range in primary Chronic Lymphocytic Leukemia and Mantle Cell Lymphoma patient samples. "
2.	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 04/13/2018 - "Ex vivo, S55746 induces apoptosis in the low nanomolar range in primary Chronic Lymphocytic Leukemia and Mantle Cell Lymphoma patient samples. "
3.	Neoplasms (Cancer) 04/13/2018 - "Finally, S55746 administered by oral route daily in mice demonstrated robust anti-tumor efficacy in two hematological xenograft models with no weight lost and no change in behavior. " 04/13/2018 - "S55746 is a novel orally active BCL-2 selective and potent inhibitor that impairs hematological tumor growth."
4.	Leukemia 01/01/2019 - "Finally, S55746 combined with S63845 prolonged survival in xenograft models of AML and suppressed patient-derived leukemia but not normal hematopoietic cells in bone marrow of engrafted mice. "
5.	Chondrosarcoma 09/21/2018 - "Selective inhibition of Bcl-2 (S55746) or Bcl-xl (WEHI-539 or A-1155463) and the combination with doxorubicin or cisplatin was investigated in a panel of 8 chondrosarcoma cell lines using presto blue viability assays and caspase 3/7 glo apoptosis assays. "

Related Drugs and Biologics

1.	Caspase 3 (Caspase-3)
2.	Doxorubicin (Adriamycin)
3.	Cisplatin (Platino)
4.	S63845