HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

CASIN

Cdc42 activity-specific inhibitor

Also Known As:

2-((6-phenyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)amino)ethanol

Networked: 6 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - Carbazoles: 32
        CASIN: 6
  - 3-Ring Heterocyclic Compounds
    - Carbazoles: 32
      - CASIN: 6

Experts

1.	Zheng, Yi: 3 articles (01/2021 - 01/2019)
2.	Duan, Xin: 2 articles (01/2021 - 01/2019)
3.	Guo, Fukun: 2 articles (01/2019 - 01/2019)
4.	Kalim, Khalid W: 2 articles (01/2019 - 01/2019)
5.	Li, Yuan: 2 articles (01/2019 - 01/2019)
6.	Nguyen, Phuong: 2 articles (01/2019 - 01/2019)
7.	Chatla, Srinivas: 1 article (11/2021)
8.	Chowdhury, Fabliha Ahmed: 1 article (11/2021)
9.	Du, Wei: 1 article (11/2021)
10.	Geldenhuys, Werner: 1 article (11/2021)

Related Diseases

1.	Thrombosis (Thrombus) 01/01/2021 - "In this study, we investigated a hypothesis that inhibition of Cdc42 activity by CASIN, a small molecule Cdc42 Activity-Specific INhibitor, may down regulate platelet activation and thrombus formation. " 01/01/2021 - "We investigated the effects of CASIN on platelet activation in vitro and thrombosis in vivo. "
2.	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 11/26/2021 - "Quinacrine-CASIN combination overcomes chemoresistance in human acute lymphoid leukemia."
3.	Pancreatic Neoplasms (Pancreatic Cancer) 11/01/2022 - "Antitumor T-cell immunity in Treg cell-specific heterozygous Cdc42 knockout mice, CASIN-treated C57BL/6 mice, humanized NSGS mice, and control mice was assessed by challenging the mice with MC38 mouse colon cancer cells, KPC mouse pancreatic cancer cells, or HCT116 human colon cancer cells. "
4.	Leukemia 11/26/2021 - "Introduction of Cdc42 Activity Specific Inhibitor, CASIN, enhances the eradication of ALL leukemia stem cells by AraC+QC and prolongs the survival of both primary and secondary transplanted recipients without affecting normal long-term human hematopoiesis. "
5.	Inflammation (Inflammations) 01/01/2019 - "CASIN had no effect on established allergic airway inflammation. " 01/01/2019 - "CASIN-treated Cdc42-deficient mice showed comparable allergic airway inflammation to vehicle-treated Cdc42-deficient mice, indicative of negligible off-target effect of CASIN. " 01/01/2019 - "CASIN also alleviated allergic airway inflammation. "

Related Drugs and Biologics

1.	Soybean Proteins (Soy Protein)
2.	Quinacrine (Mepacrine)
3.	Proteins (Proteins, Gene)
4.	Melphalan (Alkeran)
5.	Glutens (Glutelin)