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GDC-0334

Also Known As:

(4R,5S)-4-Fluoro-1-((4-fluorophenyl)sulfonyl)-5-methyl-N-((5-(trifluoromethyl)-2-(2-(trifluoromethyl)pyrimidin-5-yl)pyridin-4-yl)methyl)-L-prolinamide

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - GDC-0334: 2
  - Pyridines: 88
    - GDC-0334: 2

Experts

1.	Bauer, Rebecca N: 2 articles (01/2021 - 01/2021)
2.	Chen, Liuxi: 2 articles (01/2021 - 01/2021)
3.	Ding, Han Ting: 2 articles (01/2021 - 01/2021)
4.	Gao, Simon S: 2 articles (01/2021 - 01/2021)
5.	Joseph, Victory: 2 articles (01/2021 - 01/2021)
6.	Liederer, Bianca M: 2 articles (01/2021 - 01/2021)
7.	Yang, Xiaoying: 2 articles (01/2021 - 01/2021)
8.	Arthur, Christopher P: 1 article (01/2021)
9.	Austin, Cary D: 1 article (01/2021)
10.	Balestrini, Alessia: 1 article (01/2021)

Related Diseases

1.	Pain (Aches) 01/01/2021 - "In a healthy volunteer Phase 1 study, treatment with GDC-0334 reduced TRPA1 agonist-induced DBF, pain, and itch, demonstrating GDC-0334 target engagement in humans. "
2.	Respiratory Tract Diseases (Respiratory Tract Disease) 01/01/2021 - "GDC-0334 is a novel small molecule inhibitor of transient receptor potential cation channel member A1 (TRPA1), a promising therapeutic target for many nervous system and respiratory diseases. "
3.	Inflammation (Inflammations) 01/01/2021 - "GDC-0334 inhibited TRPA1 function on airway smooth muscle and sensory neurons, decreasing edema, dermal blood flow (DBF), cough, and allergic airway inflammation in several preclinical species. "
4.	Edema (Dropsy) 01/01/2021 - "GDC-0334 inhibited TRPA1 function on airway smooth muscle and sensory neurons, decreasing edema, dermal blood flow (DBF), cough, and allergic airway inflammation in several preclinical species. "
5.	Cough 01/01/2021 - "GDC-0334 inhibited TRPA1 function on airway smooth muscle and sensory neurons, decreasing edema, dermal blood flow (DBF), cough, and allergic airway inflammation in several preclinical species. "

Related Drugs and Biologics

1.	Transient Receptor Potential Channels