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1,1'- (4,4'- (((5- chloropyrimidine- 2,4- diyl)bis(azanediyl))bis(3- methoxy- 4,1- phenylene))bis(piperazine- 4,1- diyl))diethanone

ALK inhibitor

Also Known As:

ALK inhibitor KRCA-0008; KRCA-0008

Networked: 2 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - 1,1'-(4,4'-(((5-chloropyrimidine-2,4-diyl)bis(azanediyl))bis(3-methoxy-4,1-phenylene))bis(piperazine-4,1-diyl))diethanone: 2
  - Piperazines: 26
    - 1,1'-(4,4'-(((5-chloropyrimidine-2,4-diyl)bis(azanediyl))bis(3-methoxy-4,1-phenylene))bis(piperazine-4,1-diyl))diethanone: 2

Experts

1.	Kim, Hyoung Rae: 2 articles (10/2020 - 08/2015)
2.	Lee, Kwangho: 2 articles (10/2020 - 08/2015)
3.	Ahn, Sung-Hoon: 1 article (10/2020)
4.	Hong, Eun-Hye: 1 article (10/2020)
5.	Hwang, Jung Soon: 1 article (10/2020)
6.	Hwang, Jungjoong: 1 article (10/2020)
7.	Lee, Jongkook: 1 article (10/2020)
8.	Song, Insuk: 1 article (10/2020)
9.	Cho, Sung Yun: 1 article (08/2015)
10.	Choi, Sang Un: 1 article (08/2015)

Related Diseases

1.	Neoplasms (Cancer) 10/01/2020 - "Additionally, it induced G0/G1 cell cycle arrest and apoptosis by blocking downstream signals including STAT3, Akt, and ERK1/2. Tumor growth was strongly suppressed in mice inoculated with Karpas-299 tumor xenografts and orally treated with KRCA-0008 (50 mg/kg, BID) for 2 weeks. " 08/28/2015 - "In vivo H3122 xenograft assay, we found that KRCA-0080 shows significant reduction in tumor size compared to crizotinib and KRCA-0008 by 15-20%. " 10/01/2020 - "We evaluated the anti-cancer activity of the ALK inhibitor KRCA-0008 using ALCL cell lines that express NPM (nucleophosmin)-ALK. " 08/28/2015 - "Here, we show the newly synthesized and potent ALK inhibitor having similar scaffold to KRCA-0008, which was reported previously, and its molecular mechanism against cancer cells harboring EML4-ALK fusion protein. "
2.	Anaplastic Large-Cell Lymphoma (Ki 1 Lymphoma) 10/01/2020 - "KRCA-0008 suppresses ALK-positive anaplastic large-cell lymphoma growth."

Related Drugs and Biologics

1.	Crizotinib
2.	Proteins (Proteins, Gene)
3.	Nucleophosmin