6-(trifluoroacetamido)-1-hexanoicanilide

Class II Histone deacetylases- specific radiotracers

Also Known As:

((18)F) TFAHA; ((18)F)TFAHA; (18F)TFAHA; 6-(((18)F)tri-fluoroacetamido)-1-hexanoicanilide; 6-(((18)F)trifluoroacetamido)-1-hexanoicanilide; 6-(tri-fluoroacetamido)-1-hexanoicanilide; TFAHA

Networked: 2 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133

Experts

1.	Bonomi, Robin E: 2 articles (01/2022 - 01/2019)
2.	Gelovani, David J: 2 articles (01/2022 - 01/2019)
3.	Gelovani, Juri G: 2 articles (01/2022 - 01/2019)
4.	Mangner, Thomas: 2 articles (01/2022 - 01/2019)
5.	Potukutchi, Shreya: 2 articles (01/2022 - 01/2019)
6.	Arap, Wadih: 1 article (01/2022)
7.	Cavanaugh, John M: 1 article (01/2022)
8.	Conti, Alana: 1 article (01/2022)
9.	Kallakuri, Srinivasu: 1 article (01/2022)
10.	Kamal, Swatabdi R: 1 article (01/2022)

Related Diseases

1.	Glioma (Gliomas) 01/01/2019 - "In this study, we demonstrated the efficacy of PET/CT/(MRI) with [18F]TFAHA for non-invasive and quantitative imaging of HDAC class IIa expression-activity in intracerebral 9L and U87-MG gliomas in rats. " 01/01/2019 - "Molecular imaging HDACs class IIa expression-activity and pharmacologic inhibition in intracerebral glioma models in rats using PET/CT/(MRI) with [18F]TFAHA." 01/01/2019 - "Thus, PET/CT/(MRI) with [18F]TFAHA can facilitate studies to elucidate the roles of HDAC class IIa enzymes in gliomagenesis and progression and to optimize therapeutic doses of novel HDACs class IIa inhibitors in gliomas."
2.	Neoplasms (Cancer) 01/01/2019 - "Increased accumulation of [18F]TFAHA in 9L and U87-MG tumors was observed at 20 min post radiotracer administration with SUV of 1.45 ± 0.05 and 1.08 ± 0.05, respectively, and tumor-to-cortex SUV ratios of 1.74 ± 0.07 and 1.44 ± 0.03, respectively. " 01/01/2019 - "Significant reduction in [18F]TFAHA accumulation in 9L tumors was observed after administration of HDACs class IIa specific inhibitor MC1568, but not the SIRT1 specific inhibitor EX-527. "
3.	Brain Concussion (Cerebral Concussion) 01/01/2022 - "In this study, PET/CT with 6-([18F]trifluoroacetamido)-1- hexanoicanilide ([18F]TFAHA) to image spatial and temporal dynamics of HDACs class IIa expression-activity in brains of adult rats subjected to a weight drop model of diffuse, non-penetrating, mild traumatic brain injury (mTBI). "

Related Drugs and Biologics

1.	Sirtuin 1
2.	MC1568
3.	6- chloro- 2,3,4,9- tetrahydro- 1H- carbazole- 1- carboxamide
4.	Enzymes