anti-aquaporin 4 autoantibody

Also Known As:

AQP4-Ab; Anti-AQP4 autoantibodies; Anti-AQP4 autoantibody; Anti-aquaporin 4 autoantibodies; Anti-aquaporin4 autoantibodies; Anti-aquaporin4 autoantibody; anti-aquaporin 4 antibody; aquaporin 4 autoantibody; aquaporin4 autoantibody

Networked: 141 relevant articles (2 outcomes, 12 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Blood Proteins: 12459
    - Serum Globulins: 553
      - Immunoglobulins: 30480
        Antibodies: 133716
        Autoantibodies: 35785
        anti-aquaporin 4 autoantibody: 141
    - Immunoproteins: 43
      - Immunoglobulins: 30480
        Antibodies: 133716
        Autoantibodies: 35785
        anti-aquaporin 4 autoantibody: 141
  - Globulins: 3062
    - Serum Globulins: 553
      - Immunoglobulins: 30480
        Antibodies: 133716
        Autoantibodies: 35785
        anti-aquaporin 4 autoantibody: 141

Experts

1.	Takahashi, Toshiyuki: 13 articles (04/2019 - 03/2009)
2.	Tanaka, Keiko: 11 articles (10/2019 - 09/2007)
3.	Palace, Jacqueline: 9 articles (01/2021 - 11/2013)
4.	Waters, Patrick: 8 articles (10/2021 - 11/2010)
5.	Jarius, Sven: 8 articles (07/2017 - 05/2010)
6.	Wildemann, Brigitte: 8 articles (07/2017 - 05/2010)
7.	Paul, Friedemann: 6 articles (01/2018 - 09/2010)
8.	Vincent, Angela: 6 articles (07/2017 - 11/2010)
9.	Fujihara, Kazuo: 6 articles (01/2016 - 05/2008)
10.	Marignier, Romain: 5 articles (01/2021 - 11/2010)

Related Diseases

1.	Optic Neuritis (Retrobulbar Neuritis) 03/01/2016 - "Patients with MOG-abs in AQP4-ab seronegative LETM have clinical distinctive features, higher risk of optic neuritis relapses, and better outcome than patients seronegative." 12/15/2018 - "Ten studies were enrolled and the results showed that the degree of RNFL loss in MOG-ab-positive optic neuritis patients may not differ from that of AQP4-ab patients. " 04/01/2019 - "Clinical Characteristics of Anti-aquaporin 4 Antibody Positive Optic Neuritis in Japan." 10/01/2017 - "AQP4-Ab was detectable in 70/215 (32.6%) patients with acute monosymptomatic optic neuritis. " 10/01/2017 - "The objective is to assess the frequency of AQP4-Ab in Chinese patients with optic neuritis (ON) and to investigate the prognostic implications of AQP4-Ab seropositivity in such patients. "
2.	Demyelinating Diseases (Demyelinating Disease) 11/01/2018 - "AQP4-Ab test was positive for one-tenth of patients with CNS inflammatory demyelinating diseases other than typical MS in our study. " 04/29/2014 - "Further population-based studies with AQP4-Ab are needed to determine the exact incidence of NMO and other idiopathic inflammatory demyelinating diseases in Korea." 07/18/2017 - "A diagnostic algorithm applicable to any episode of CNS demyelination leads to 4 main phenotypes: MS, AQP4-Ab NMOSD, MOG-Ab-associated disease, and antibody-negative RDS. " 01/01/2017 - "The Prevalence of Anti-Aquaporin 4 Antibody in Patients with Idiopathic Inflammatory Demyelinating Diseases Presented to a Tertiary Hospital in Malaysia: Presentation and Prognosis." 04/01/2015 - "Twenty NMO cases (females = 90%; AQP4-Ab positive = 60%; median age = 10.5 yrs) with median follow-up = 6.1 yrs were compared to a national cohort sample of known sequential AQP4-Ab negative first episode CNS acquired demyelination cases (n = 29; females = 55%; all AQP4-Ab negative; median age = 13.6 yrs). "
3.	Neuromyelitis Optica (Devic's Disease) 01/01/2023 - "Treatment De-escalation in AQP4-Ab Neuromyelitis Optica Spectrum Disorder." 09/16/2021 - "NMO spectrum disorder (NMOSD) has recently been defined and stratified based on AQP4-ab serology status. " 01/01/2021 - "Pregnancy in Patients With AQP4-Ab, MOG-Ab, or Double-Negative Neuromyelitis Optica Disorder." 01/01/2021 - "Comparison of clinical characteristics and prognoses in patients with different AQP4-Ab and MOG-Ab serostatus with neuromyelitis optica spectrum disorders." 05/01/2020 - "Neuromyelitis optica spectrum disorders in South of Tunisia: A rare entity with low seroprevalence of anti-aquaporin 4 autoantibodies."
4.	Multiple Sclerosis 01/01/2022 - "By contrast to patients with radiologically isolated syndrome, of which some will never convert to multiple sclerosis, the pathogenicity of AQP4-Ab in the context of sub-clinical disease, supported treatment in our patient. " 01/01/2020 - "Therefore, we compared AQP4 and MOG specific peripheral T-cell response in individuals with AQP4-Ab (n = 8), MOG-Ab (n = 10), multiple sclerosis (MS, n = 8), and healthy controls (HC, n = 14). " 07/01/2013 - "The clinical and radiological characteristics of 78 patients with NMOSD and 22 with multiple sclerosis (MS), who were tested for AQP4-Ab by a cell-based assay, were assessed. " 05/01/2012 - "We measured AQP4-Ab in the sera of 300 individuals: 64 with definite NMO, 31 with high-risk NMO, 105 with multiple sclerosis (MS), 57 with other neurological diseases (ONDs), and 43 healthy controls. " 11/01/2007 - "[Anti-aquaporin 4 antibody in Japanese multiple sclerosis with long spinal cord lesions]."
5.	Systemic Lupus Erythematosus (Libman-Sacks Disease) 05/19/2023 - "This study aimed to describe the prevalence of the various clinical features and severity of juvenile systemic lupus erythematosus (jSLE) and to assess predictors of AQP4-Ab positivity in jSLE. " 09/01/2019 - "We suggest that all juvenile systemic lupus erythematosus patients should be systematically screened for the presence of AQP4-Ab and this may help identify a high risk for neurological involvement in juvenile systemic lupus erythematosus." 09/01/2019 - "Sera from 90 patients with juvenile systemic lupus erythematosus were tested for the presence of AQP4-Ab using a cell-based assay. " 05/19/2023 - "For 90 patients with jSLE, demographic data, clinical manifestations, and treatments received were recorded, and all of the patients were underwent clinical examinations, including assessments for the neurological manifestations of jSLE and neuropsychiatric disorders; Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) score evaluations; laboratory investigations, including serum AQP4-Ab assays; and 1.5 Tesla brain MRI. " 09/01/2011 - "However, AQP4-Ab has been found also in patients with co-existing rheumatic diseases such as systemic lupus erythematosus (SLE) or Sjögren's syndrome (SS), conditions which are characterized by broad, polyspecific B cell activation. "

Related Drugs and Biologics

1.	Biomarkers (Surrogate Marker)
2.	Antibodies
3.	Myelin-Oligodendrocyte Glycoprotein
4.	Retinaldehyde (Retinal)
5.	Aquaporin 4
6.	Vaccines
7.	Autoantibodies
8.	Rituximab (Mabthera)
9.	Complement System Proteins (Complement)
10.	Antigens

Related Therapies and Procedures

1.	Therapeutics
2.	Trabeculectomy (Trabeculoplasty)
3.	Thymectomy
4.	Plasma Exchange
5.	Immunotherapy