anti-CASPR2 autoantibody

Autoantibodies against contactin-associated protein-like 2 (CASPR2). Presence of anti-CASPR2 auto antibodies is associated with CORTICAL DYSPLASIA-FOCAL EPILEPSY SYNDROME.

Also Known As:

Anti-CASPR2 autoantibodies; Anti-contactin associated protein-like 2 autoantibodies; Anti-contactin associated protein-like 2 autoantibody; CASPR2 autoantibodies; anti-CNTNAP2 CASPR2 autoantibodies; anti-CNTNAP2 CASPR2 autoantibody; anti-CNTNAP2 autoantibodies; anti-CNTNAP2 autoantibody

Networked: 12 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Blood Proteins: 12459
    - Serum Globulins: 553
      - Immunoglobulins: 30480
        Antibodies: 133716
        Autoantibodies: 35785
        anti-CASPR2 autoantibody: 12
    - Immunoproteins: 43
      - Immunoglobulins: 30480
        Antibodies: 133716
        Autoantibodies: 35785
        anti-CASPR2 autoantibody: 12
  - Globulins: 3062
    - Serum Globulins: 553
      - Immunoglobulins: 30480
        Antibodies: 133716
        Autoantibodies: 35785
        anti-CASPR2 autoantibody: 12

Experts

1.	Honnorat, Jérôme: 3 articles (01/2019 - 01/2015)
2.	Saint-Martin, Margaux: 3 articles (01/2019 - 01/2015)
3.	Karagogeos, Domna: 2 articles (01/2019 - 01/2015)
4.	Noraz, Nelly: 2 articles (01/2019 - 01/2019)
5.	Pinatel, Delphine: 2 articles (01/2019 - 01/2015)
6.	Coutinho, Ester: 2 articles (01/2018 - 01/2017)
7.	Jacobson, Leslie: 2 articles (01/2018 - 01/2017)
8.	Vincent, Angela: 2 articles (01/2018 - 01/2017)
9.	Butler, Ian J: 1 article (02/2020)
10.	Pérez, Carlos A: 1 article (02/2020)

Related Diseases

1.	Limbic Encephalitis (Paraneoplastic Limbic Encephalitis) 01/01/2015 - "Inhibitory axons are targeted in hippocampal cell culture by anti-Caspr2 autoantibodies associated with limbic encephalitis." 01/01/2019 - "Accumulating evidence has showed that anti-CASPR2 autoantibodies occur in a long list of neurological immune disorders including limbic encephalitis (LE). "
2.	Psychotic Disorders (Schizoaffective Disorder) 01/01/2020 - "Commentary on "Psychosis associated to CASPR2 autoantibodies and ovarian teratoma: A case report"." 01/01/2020 - "Psychosis associated to CASPR2 autoantibodies and ovarian teratoma: A case report."
3.	Pain (Aches) 01/01/2018 - "Human CASPR2 autoantibodies, when injected into mice, were peripherally restricted and resulted in mechanical pain-related hypersensitivity in the absence of neural injury. " 01/01/2023 - "For example, passive transfer of CASPR2 autoantibodies from patients cause increased pain sensitivity and enhanced sensory neuron excitability in mice confirming pathogenicity and demonstrating that patient autoantibodies are a mechanism to cause neuropathic pain. "
4.	Glioma (Gliomas) 06/01/2023 - "The coexistence of leucine-rich glioma-inactivated 1 (LGI1) and contactin-associated protein-like 2 (CASPR2) autoantibodies in the same individual is surprisingly often observed. " 02/22/2020 - "In addition to the characteristic anti-leucine-rich glioma-inactivated protein 1 (LGI1) and anti-contactin-associated protein-like 2 (Caspr2) autoantibodies, glutamic acid decarboxylase 65-kilodalton isoform (GAD65), and N-type and P/Q-type voltage-gated calcium channel (VGCC) antibodies were detected. "
5.	Ovarian Teratoma 01/01/2020 - "Commentary on "Psychosis associated to CASPR2 autoantibodies and ovarian teratoma: A case report"." 01/01/2020 - "Psychosis associated to CASPR2 autoantibodies and ovarian teratoma: A case report."

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Leucine (L-Leucine)
3.	Protein Isoforms (Isoforms)
4.	Calcium Channels (Calcium Channel)
5.	Glutamate Decarboxylase (Decarboxylase, Glutamate)
6.	Autoantibodies
7.	Antibodies