orludodstat

Also Known As:

BAY 2402234; BAY-2402234; N-(2-chloro-6-fluorophenyl)-4-(4-ethyl-3-(hydroxymethyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl)-5-fluoro-2-(((2S)-1,1,1-trifluoropropan-2-yl)oxy)benzamide

Networked: 2 relevant articles (2 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Aniline Compounds: 46
    - Anilides: 22
      - Salicylanilides: 18
        orludodstat: 2
- Amides: 2428
  - Anilides: 22
    - Salicylanilides: 18
      - orludodstat: 2
  - Salicylamides: 2
    - Salicylanilides: 18
      - orludodstat: 2
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Triazoles: 1533
      - orludodstat: 2

Experts

1.	Bauser, Marcus: 1 article (10/2019)
2.	Brzezinka, Krzysztof: 1 article (10/2019)
3.	Christian, Sven: 1 article (10/2019)
4.	Eheim, Ashley: 1 article (10/2019)
5.	Evans, Laura: 1 article (10/2019)
6.	Ferrara, Steven: 1 article (10/2019)
7.	Friberg, Anders: 1 article (10/2019)
8.	Gradl, Stefan: 1 article (10/2019)
9.	Haegebarth, Andrea: 1 article (10/2019)
10.	Janzer, Andreas: 1 article (10/2019)

Related Diseases

1.	Neoplasms (Cancer) 10/01/2019 - "The novel dihydroorotate dehydrogenase (DHODH) inhibitor BAY 2402234 triggers differentiation and is effective in the treatment of myeloid malignancies."
2.	Glioma (Gliomas) 12/01/2022 - "We developed a genetically engineered mouse model of mutant IDH1-driven astrocytoma and used it and multiple patient-derived models to show that the brain-penetrant DHODH inhibitor BAY 2402234 displays monotherapy efficacy against IDH-mutant gliomas. "
3.	Astrocytoma (Pilocytic Astrocytoma) 12/01/2022 - "We developed a genetically engineered mouse model of mutant IDH1-driven astrocytoma and used it and multiple patient-derived models to show that the brain-penetrant DHODH inhibitor BAY 2402234 displays monotherapy efficacy against IDH-mutant gliomas. "

Related Drugs and Biologics

1.	Dihydroorotate Dehydrogenase