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SETD7 inhibitor PFI-2

Also Known As:

8-Fluoro-1,2,3,4-tetrahydro-N-((1R)-2-oxo-2-(1-pyrrolidinyl)-1-((3-(trifluoromethyl)phenyl)methyl)ethyl)-6-isoquinolinesulfonamide hydrochloride; pfi-2

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Isoquinolines: 34
      - SETD7 inhibitor PFI-2: 3
Organic Chemicals: 133
- Amides: 2428
  - Sulfonamides: 2809
    - SETD7 inhibitor PFI-2: 3
- Sulfur Compounds: 278
  - Sulfones: 534
    - Sulfonamides: 2809
      - SETD7 inhibitor PFI-2: 3

Experts

1.	Huang, Jiangju: 1 article (06/2021)
2.	Liang, Hua: 1 article (06/2021)
3.	Liang, Zijie: 1 article (06/2021)
4.	Liu, Benquan: 1 article (06/2021)
5.	Nie, Jiayi: 1 article (06/2021)
6.	Wen, Shihong: 1 article (06/2021)
7.	Yu, Wenqiang: 1 article (06/2021)
8.	Ding, Zhuofeng: 1 article (11/2019)
9.	Ding, Zijin: 1 article (11/2019)
10.	Guo, Qulian: 1 article (11/2019)

Related Diseases

1.	Periodontal Diseases (Periodontal Disease) 11/01/2022 - "To address the loss of periodontal bone and connective tissues following periodontal disease, we have generated a polydopamine and collagen coated electrospun PLGA-PCL (PP) scaffold enriched with the small molecule mediator PFI-2 (PP-PFI-pDA-COL-PFI). "
2.	Neuralgia (Stump Neuralgia) 11/01/2019 - "Moreover, intrathecal administration of PFI-2 alleviated CCI-induced neuropathic pain. "
3.	Fibrosis (Cirrhosis) 06/15/2021 - "Mice treated with PFI-2, an inhibitor of SETD7, presented less bone marrow-derived myofibroblasts, fewer CD206+/α-smooth muscle actin + cells and developed less renal fibrosis (P＜0.01). " 06/15/2021 - "Pharmacological inhibition of SETD7 by PFI-2 attenuates renal fibrosis following folic acid and obstruction injury."

Related Drugs and Biologics

1.	Folic Acid (Vitamin M)
2.	Collagen
3.	polydopamine