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JME-173

mexiletine derivative

Also Known As:

1-(4-bromo-3,5-dimethylphenoxy)propan-2-amine

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Propylamines: 1
    - Mexiletine: 762
      - JME-173: 2
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenols: 677
        Phenyl Ethers: 8
        Mexiletine: 762
        JME-173: 2

Experts

1.	Coutinho, Diego de Sá: 2 articles (10/2020 - 01/2020)
2.	Faria, Robson Xavier: 2 articles (10/2020 - 01/2020)
3.	Martins, Marco Aurélio: 2 articles (10/2020 - 01/2020)
4.	Amendoeira, Fábio Coelho: 1 article (10/2020)
5.	Araújo, João Felipe Garcia: 1 article (10/2020)
6.	Carvalho, Katharinne Ingrid Moraes de: 1 article (10/2020)
7.	Costa, Jorge Carlos Santos da: 1 article (10/2020)
8.	Ferrero, Maximiliano R: 1 article (10/2020)
9.	Fonseca, Laís Bastos da: 1 article (10/2020)
10.	Pereira, Heliana Martins: 1 article (10/2020)

Related Diseases

1.	Pneumonia (Pneumonitis) 10/15/2020 - "JME-173 was then studied in vivo using a murine model of lung inflammation induced by cigarette smoke (CS) and in vitro using neutrophil chemotaxis and mast cell degranulation assays. " 01/01/2020 - "In addition, JME-173 also inhibited AHR in a mouse model of lipopolysaccharide (LPS)-induced lung inflammation. "
2.	Inflammation (Inflammations) 10/15/2020 - "Collectively, these findings suggest that JME-173 has the potential to be an effective oral treatment for diseases associated with bronchoconstriction and inflammation."
3.	Bronchial Spasm 01/01/2020 - "When orally administered, JME-173 and theophylline inhibited methacholine-induced bronchospasm at time points of 1 and 3 h post-treatment, while only JME-173 remained active for at least 6 h. "

Related Drugs and Biologics

1.	Methacholine Chloride (Methacholine)
2.	Theophylline (Theon)
3.	Smoke
4.	Lipopolysaccharides