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4'-fluorouridine

Also Known As:

EIDD 2749; EIDD-2749

Networked: 3 relevant articles (2 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrimidines: 510
    - Pyrimidine Nucleotides: 48
      - Uracil Nucleotides: 40
        4'-fluorouridine: 3
Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleotides: 15763
  - Ribonucleotides: 307
    - Uracil Nucleotides: 40
      - 4'-fluorouridine: 3
  - Pyrimidine Nucleotides: 48
    - Uracil Nucleotides: 40
      - 4'-fluorouridine: 3

Experts

1.	Aggarwal, Megha: 1 article (05/2021)
2.	Bluemling, Gregory R: 1 article (05/2021)
3.	Cox, Robert M: 1 article (05/2021)
4.	Kolykhalov, Alexander A: 1 article (05/2021)
5.	Lieber, Carolin M: 1 article (05/2021)
6.	Martinez-Sobrido, Luis: 1 article (05/2021)
7.	Natchus, Michael G: 1 article (05/2021)
8.	Painter, George R: 1 article (05/2021)
9.	Plemper, Richard K: 1 article (05/2021)
10.	Sourimant, Julien: 1 article (05/2021)

Related Diseases

1.	Influenza in Birds (Avian Flu) 01/01/2023 - "4'-Fluorouridine mitigates lethal infection with pandemic human and highly pathogenic avian influenza viruses." 10/21/2023 - "We have recently identified the chain-terminating broad-spectrum nucleoside analog clinical candidate 4'-fluorouridine (4'-FlU) and demonstrated oral efficacy against seasonal, pandemic, and highly pathogenic avian influenza viruses in the mouse and ferret model. "
2.	Viral Pneumonia 01/01/2023 - "Having previously identified oral efficacy of the nucleoside analog 4'-Fluorouridine (4'-FlU, EIDD-2749) against SARS-CoV-2 and respiratory syncytial virus (RSV), we explored activity of the compound against seasonal and highly pathogenic influenza (HPAI) viruses in cell culture, human airway epithelium (HAE) models, and/or two animal models, ferrets and mice, that assess IAV transmission and lethal viral pneumonia, respectively. "
3.	Human Influenza (Influenza) 01/01/2023 - "Having previously identified oral efficacy of the nucleoside analog 4'-Fluorouridine (4'-FlU, EIDD-2749) against SARS-CoV-2 and respiratory syncytial virus (RSV), we explored activity of the compound against seasonal and highly pathogenic influenza (HPAI) viruses in cell culture, human airway epithelium (HAE) models, and/or two animal models, ferrets and mice, that assess IAV transmission and lethal viral pneumonia, respectively. "
4.	Infections 01/01/2023 - "4'-Fluorouridine mitigates lethal infection with pandemic human and highly pathogenic avian influenza viruses."
5.	COVID-19 05/20/2021 - "4'-Fluorouridine is an orally available ribonucleoside analog that efficiently treats RSV and SARS-CoV-2 infections in vivo ."

Related Drugs and Biologics

1.	Nucleosides