EC5026

epoxide hydrolase inhibitor

Also Known As:

1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-3-(1-((2S)-2-methylbutanoyl)-4-piperidinyl)urea; Urea, N-(3-fluoro-4-(trifluoromethoxy)phenyl)-N'-(1-((2S)-2-methyl-1-oxobutyl)-4-piperidinyl)-

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amides: 2428
  - Urea: 15015
    - Phenylurea Compounds: 1
      - EC5026: 3
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenylurea Compounds: 1
        EC5026: 3

Experts

1.	Buckpitt, Alan: 1 article (01/2021)
2.	Cortes-Puch, Irene: 1 article (01/2021)
3.	Croston, Glenn: 1 article (01/2021)
4.	Hammock, Bruce D: 1 article (01/2021)
5.	Hwang, Sung Hee: 1 article (01/2021)
6.	Lee, Kin Sing Stephen: 1 article (01/2021)
7.	McReynolds, Cindy B: 1 article (01/2021)
8.	Schmidt, William K: 1 article (01/2021)
9.	Wagner, Karen: 1 article (01/2021)
10.	Yang, Jun: 1 article (01/2021)

Related Diseases

1.	Pain (Aches) 01/05/2024 - "EC5026 is a soluble epoxide hydrolase (SEH) inhibitor which is being developed clinically (Phase-1) as a first-in-class analgesic for the treatment of pain. " 01/01/2021 - "EC5026 acts on the cytochrome P450 branch of the arachidonate cascade to stabilize epoxides of polyunsaturated fatty acids (EpFA), which are natural mediators that reduce pain, resolve inflammation, and maintain normal blood pressure. " 01/01/2022 - "Doses of EC5026, an IND candidate intended to treat neuropathic pain, elicited dose dependent analgesic responses in multiple models including platinum-based, taxane, and vinca alkaloid-based CIPN pain in Sprague Dawley rats. "
2.	Neuralgia (Stump Neuralgia) 01/01/2021 - "Movement to the Clinic of Soluble Epoxide Hydrolase Inhibitor EC5026 as an Analgesic for Neuropathic Pain and for Use as a Nonaddictive Opioid Alternative." 01/01/2022 - "Doses of EC5026, an IND candidate intended to treat neuropathic pain, elicited dose dependent analgesic responses in multiple models including platinum-based, taxane, and vinca alkaloid-based CIPN pain in Sprague Dawley rats. "
3.	Inflammation (Inflammations) 01/01/2021 - "EC5026 acts on the cytochrome P450 branch of the arachidonate cascade to stabilize epoxides of polyunsaturated fatty acids (EpFA), which are natural mediators that reduce pain, resolve inflammation, and maintain normal blood pressure. "

Related Drugs and Biologics

1.	Analgesics (Analgesic Drugs)
2.	Epoxide Hydrolases
3.	Platinum
4.	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)
5.	Epoxy Compounds (Epoxides)
6.	Cytochrome P-450 Enzyme System (Cytochrome P450)
7.	Opioid Analgesics (Opioids)
8.	Alkaloids
9.	taxane