HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

ONO-8590580

GABA A alpha 5 receptor negative allosteric modulator

Also Known As:

1-(cyclopropylmethyl)-5-fluoro-4-methyl-N-(5-(1-methyl-1H-imidazol-4-yl)pyridin-2-yl)-1H-benzo(d)imidazol-6-amine

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - ONO-8590580: 1
  - Pyridines: 88
    - ONO-8590580: 1

Experts

1.	Chambers, Mark S: 1 article (01/2018)
2.	Clark, Gary S: 1 article (01/2018)
3.	Hazama, Keisuke: 1 article (01/2018)
4.	Higashino, Masato: 1 article (01/2018)
5.	Kaneko, Shuji: 1 article (01/2018)
6.	Katsumata, Seishi: 1 article (01/2018)
7.	Kawaharada, Soichi: 1 article (01/2018)
8.	Lewis, Arwel: 1 article (01/2018)
9.	Maidment, Scott A: 1 article (01/2018)
10.	Nakanishi, Miki: 1 article (01/2018)

Related Diseases

1.	Tetanus 01/01/2018 - "ONO-8590580 [1-(cyclopropylmethyl)-5-fluoro-4-methyl-N-[5-(1-methyl-1H-imidazol-4-yl)-2-pyridinyl]-1H-benzimidazol-6-amine] binds to the benzodiazepine binding sites on recombinant human α5-containing GABAA receptors with a Ki of 7.9 nM, and showed functionally selective GABAAα5 NAM activity for GABA-induced Cl- channel activity with a maximum 44.4% inhibition and an EC50 of 1.1 nM. In rat hippocampal slices, tetanus-induced long-term potentiation of CA1 synapse response was significantly augmented in the presence of 300 nM ONO-8590580. "
2.	Memory Disorders (Memory Loss) 01/01/2018 - "In the rat passive avoidance test, ONO-8590580 (3-20 mg/kg, by mouth) significantly prevented (+)-MK-801 hydrogen maleate (MK-801)-induced memory deficit. "

Related Drugs and Biologics

1.	Dizocilpine Maleate (Dizocilpine)
2.	gamma-Aminobutyric Acid (GABA)
3.	Benzodiazepines
4.	Amines
5.	maleic acid (maleate)