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furimazine

Also Known As:

8-Benzyl-2-(2-furylmethyl)-6-phenylimidazo(1,2-a)pyrazin-3(7H)-one; hydrofurimazine

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds

Experts

1.	Deyev, S M: 3 articles (11/2018 - 10/2016)
2.	Proshkina, G M: 3 articles (11/2018 - 10/2016)
3.	Shramova, E I: 3 articles (11/2018 - 10/2016)
4.	Cramer, Steve J: 1 article (08/2020)
5.	Dautzenberg, Iris J C: 1 article (08/2020)
6.	Gaspar, Natasa: 1 article (08/2020)
7.	Hoeben, Rob C: 1 article (08/2020)
8.	Kirkland, Thomas A: 1 article (08/2020)
9.	Lowik, Clemens: 1 article (08/2020)
10.	Mezzanotte, Laura: 1 article (08/2020)

Related Diseases

1.	Neoplasms (Cancer) 11/01/2018 - "Luminescence systems based on furimazine and hybrid protein NanoLuc-miniSOG targeted to mitochondria or cellular membranes possess the similar energy transfer efficiencies and similar BRET-induced cytotoxic effects on cancer cells, though the mechanisms of BRET-induced cell death are different. " 09/01/2018 - "It was shown that the mechanism of cell death caused by BRET-induced phototoxicity of mimiSOG in the presence of furimazine depends on the intracellular localization of the NanoLuc-miniSOG fusion protein: BRET-mediated activation of miniSOG in mitochondrial localization causes apoptosis, while the membrane localization of PS causes necrosis of cancer cells." 10/01/2016 - "In this study, we investigated the possibility of phototoxic flavoprotein miniSOG (photosensitizer) excitation in cancer cells by bioluminescence occurring when luciferase NanoLuc oxidizes its substrate, furimazine. " 11/01/2018 - "Here we show that luciferase NanoLuc being expressed as a fusion protein with phototoxic flavoprotein miniSOG in cancer cells in the presence of furimazine (highly specific NanoLuc substrate) induces a photodynamic effect of miniSOG comparable with its LED-excited (Light Emitting Diode) phototoxicity. "
2.	Phototoxic Dermatitis (Phototoxicity) 09/01/2018 - "It was shown that the mechanism of cell death caused by BRET-induced phototoxicity of mimiSOG in the presence of furimazine depends on the intracellular localization of the NanoLuc-miniSOG fusion protein: BRET-mediated activation of miniSOG in mitochondrial localization causes apoptosis, while the membrane localization of PS causes necrosis of cancer cells." 11/01/2018 - "Here we show that luciferase NanoLuc being expressed as a fusion protein with phototoxic flavoprotein miniSOG in cancer cells in the presence of furimazine (highly specific NanoLuc substrate) induces a photodynamic effect of miniSOG comparable with its LED-excited (Light Emitting Diode) phototoxicity. "
3.	Virus Diseases (Viral Diseases) 08/15/2020 - "NanoBiT System and Hydrofurimazine for Optimized Detection of Viral Infection in Mice-A Novel in Vivo Imaging Platform." 08/15/2020 - "Here we demonstrate bioluminescent imaging of viral infection using the NanoBiT system in combination with intraperitoneal injection of a furimazine analogue, hydrofurimazine. "
4.	Necrosis 09/01/2018 - "It was shown that the mechanism of cell death caused by BRET-induced phototoxicity of mimiSOG in the presence of furimazine depends on the intracellular localization of the NanoLuc-miniSOG fusion protein: BRET-mediated activation of miniSOG in mitochondrial localization causes apoptosis, while the membrane localization of PS causes necrosis of cancer cells."

Related Drugs and Biologics

1.	nanoluc
2.	Luciferases
3.	Flavoproteins
4.	Photosensitizing Agents (Photosensitizers)
5.	Proteins (Proteins, Gene)
6.	furimazine

Related Therapies and Procedures

1.	Intraperitoneal Injections