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abp-700

Also Known As:

1-(Methoxycarbonyl)cyclopropyl 1-((1R)-1-phenylethyl)-1H-imidazole-5-carboxylate; Cyclopropyl-methoxycarbonyl metomidate

Networked: 3 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Imidazoles: 150
      - abp-700: 3

Experts

1.	Raines, Douglas E: 2 articles (01/2019 - 08/2015)
2.	Lehoux, Dario: 1 article (01/2019)
3.	Marota, John J A: 1 article (01/2019)
4.	McGrath, Megan: 1 article (01/2019)
5.	Valk, Beatrijs I: 1 article (01/2019)
6.	Zerler, Brad: 1 article (01/2019)
7.	Absalom, A R: 1 article (06/2018)
8.	Campagna, J A: 1 article (06/2018)
9.	Meier, S: 1 article (06/2018)
10.	Meyer, P: 1 article (06/2018)

Related Diseases

1.	Sepsis (Septicemia) 08/01/2015 - "Cyclopropyl-methoxycarbonyl Metomidate: Studies in a Lipopolysaccharide Inflammatory Model of Sepsis."
2.	Seizures (Absence Seizure) 01/01/2019 - "To define the relationship (if any) between involuntary muscle movements and seizures, electroencephalographic studies were performed in Beagle dogs receiving supra-therapeutic (~10× clinical) ABP-700 doses. " 01/01/2019 - "High dose ABP-700 infusions produce involuntary muscle movements and seizures in Beagle dogs via distinct mechanisms. " 01/01/2019 - "ABP-700 produced both involuntary muscle movements (14 of 14 dogs) and seizures (5 of 14 dogs). " 01/01/2019 - "The etomidate analog ABP-700 produces involuntary muscle movements that could be manifestations of seizures. " 01/01/2019 - "γ-aminobutyric acid type A (GABAA) and glycine receptor studies were undertaken to test receptor inhibition as the potential mechanism for ABP-700 seizures. "
3.	Respiratory Insufficiency (Respiratory Failure) 06/01/2018 - "Infusions of ABP-700 showed a dose-dependent hypnotic effect, and did not cause severe hypotension, severe respiratory depression, or adrenocortical suppression. "
4.	Hypotension (Low Blood Pressure) 06/01/2018 - "Infusions of ABP-700 showed a dose-dependent hypnotic effect, and did not cause severe hypotension, severe respiratory depression, or adrenocortical suppression. "

Related Drugs and Biologics

1.	Glycine Receptors (Glycine Receptor)
2.	Lipopolysaccharides
3.	Aminobutyrates (Aminobutyric Acid)
4.	Hypnotics and Sedatives (Sedatives)
5.	Etomidate