asapiprant

inhibitor of the prostaglandin D2 (PGD2) DP1 signaling pathway

Also Known As:

2-(2-(oxazol-2-yl)-5-(4-(4-((propan-2-yl)oxy)benzenesulfonyl(piperazin-1-yl)phenoxy)acetic acid; BGE 175; BGE-175; S-555739

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Oxazoles: 89
      - asapiprant: 4
  - Piperazines: 26
    - asapiprant: 4

Experts

1.	Aswad, Fred: 2 articles (01/2022 - 04/2021)
2.	Fortney, Kristen: 2 articles (01/2022 - 04/2021)
3.	Klumpp, Klaus: 2 articles (01/2022 - 04/2021)
4.	Li, Kun: 2 articles (01/2022 - 04/2021)
5.	McCray, Paul B: 2 articles (01/2022 - 04/2021)
6.	Meyerholz, David K: 2 articles (01/2022 - 04/2021)
7.	Murakami, Makoto: 2 articles (01/2022 - 04/2021)
8.	Narumiya, Shuh: 2 articles (01/2022 - 04/2021)
9.	Ortiz, Miguel E: 2 articles (01/2022 - 04/2021)
10.	Perlman, Stanley: 2 articles (01/2022 - 04/2021)

Related Diseases

1.	Allergic Rhinitis 06/01/2016 - "At least 15 selective, orally active, DP2 receptor antagonists and one DP1 receptor antagonist (asapiprant) are under development for asthma and/or allergic rhinitis. " 10/15/2015 - "Effect of the potent and selective DP1 receptor antagonist, asapiprant (S-555739), in animal models of allergic rhinitis and allergic asthma." 10/15/2015 - "In the animal models of allergic rhinitis, changes in nasal resistance, nasal secretion, and cell infiltration in nasal mucosa were assessed after antigen challenge with and without asapiprant. "
2.	Infections 01/01/2022 - "Furthermore, treatment with a PTGDR antagonist, asapiprant, protected aged mice from lethal infection. " 04/21/2021 - "Further, treatment with a DP1 antagonist, asapiprant, protected aged mice from a lethal infection. "
3.	Asthma (Bronchial Asthma) 06/01/2016 - "At least 15 selective, orally active, DP2 receptor antagonists and one DP1 receptor antagonist (asapiprant) are under development for asthma and/or allergic rhinitis. " 10/15/2015 - "Effect of the potent and selective DP1 receptor antagonist, asapiprant (S-555739), in animal models of allergic rhinitis and allergic asthma." 10/15/2015 - "Similarly, in the animal models of asthma, the effect of antigen challenge with and without asapiprant on antigen-induced bronchoconstriction, airway hyper-responsiveness, mucin production, and cell infiltration in lung were assessed. "
4.	Respiratory Hypersensitivity 10/15/2015 - "In addition, treatment with asapiprant suppressed antigen-induced asthmatic responses, airway hyper-responsiveness, and cell infiltration and mucin production in lung. " 10/15/2015 - "Similarly, in the animal models of asthma, the effect of antigen challenge with and without asapiprant on antigen-induced bronchoconstriction, airway hyper-responsiveness, mucin production, and cell infiltration in lung were assessed. "

Related Drugs and Biologics

1.	Mucins
2.	Antigens