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QTC-4-MeOBnE

Also Known As:

1-(7-chloroquinolin-4-yl)-N-(4-methoxybenzyl)-5-methyl-1H-1,2,3-triazole-4 carboxamide

Networked: 5 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Triazoles: 1533
      - QTC-4-MeOBnE: 5
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - QTC-4-MeOBnE: 5

Experts

1.	Alves, Diego: 4 articles (01/2022 - 01/2019)
2.	Baldinotti, Rodolfo: 4 articles (01/2022 - 01/2019)
3.	Fronza, Mariana G: 4 articles (01/2022 - 01/2019)
4.	Savegnago, Lucielli: 4 articles (01/2022 - 01/2019)
5.	Sacramento, Manoela: 3 articles (01/2022 - 01/2020)
6.	Collares, Tiago: 3 articles (01/2021 - 01/2019)
7.	Seixas, Fabiana K: 3 articles (01/2021 - 01/2019)
8.	Fetter, Jenifer: 2 articles (01/2022 - 01/2020)
9.	Praticò, Domenico: 2 articles (01/2022 - 01/2020)
10.	Sousa, Fernanda Severo Sabedra: 2 articles (01/2021 - 01/2020)

Related Diseases

1.	Dementia (Dementias) 01/01/2022 - "Together, our findings highlight the pharmacological benefits of QTC-4-MeOBnE in a mouse model of sickness behavior and memory impairments, supporting the novel concept that since this molecule produces anti-depressant activity, it could also be beneficial for preventing AD onset and related dementias in subjects suffering from MDD through inflammatory pathway modulation."
2.	Memory Disorders (Memory Loss) 01/01/2019 - "QTC-4-MeOBnE pretreatment attenuated cognitive and memory deficit induced by STZ in an object recognition test, Y-maze, social recognition test and step-down passive avoidance. " 01/01/2020 - "QTC-4-MeOBnE Rescues Scopolamine-Induced Memory Deficits in Mice by Targeting Oxidative Stress, Neuronal Plasticity, and Apoptosis."
3.	Alzheimer Disease (Alzheimer's Disease) 01/01/2021 - "Effect of QTC-4-MeOBnE Treatment on Memory, Neurodegeneration, and Neurogenesis in a Streptozotocin-Induced Mouse Model of Alzheimer's Disease." 01/01/2019 - "Rational design, cognition and neuropathology evaluation of QTC-4-MeOBnE in a streptozotocin-induced mouse model of sporadic Alzheimer's disease."
4.	Cognitive Dysfunction 01/01/2022 - "Beneficial effects of QTC-4-MeOBnE in an LPS-induced mouse model of depression and cognitive impairments: The role of blood-brain barrier permeability, NF-κB signaling, and microglial activation." 01/01/2022 - "Therefore, we investigated the effects of QTC-4-MeOBnE treatment (0.1 or 1 mg/kg) on depressive-like behavior and cognitive impairments elicited by repeated injections of lipopolysaccharide (LPS; 250 μg/kg) in mice. "
5.	Neuroinflammatory Diseases 03/01/2023 - "Additionally, QTC-4-MeOBnE also exerted beneficial effects on neuroinflammation and synaptic integrity. "

Related Drugs and Biologics

1.	Streptozocin (Streptozotocin)
2.	Scopolamine (Hyoscine)
3.	Lipopolysaccharides

Related Therapies and Procedures

1.	Injections