PPI-1011

DHA-containing ethanolamine plasmalogen

Also Known As:

(2R)-1-((5-((3R)-1,2-Dithiolan-3-yl)pentanoyl)oxy)-3-(hexadecyloxy)-2-propanyl (4Z,7Z,10Z,13Z,16Z,19Z)-4,7,10,13,16,19-docosahexaenoate; 1,2-Dithiolane-3-pentanoic acid, (2R)-3-(hexadecyloxy)-2-(((4Z,7Z,10Z,13Z,16Z,19Z)-1-oxo-4,7,10,13,16,19-docosahexaen-1-yl)oxy)propyl ester, (3R)-

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Lipids: 114793
- Membrane Lipids: 1591
  - Phospholipids: 11903
    - Glycerophosphates: 118
      - Phosphatidic Acids: 358
        Glycerophospholipids: 689
        Phospholipid Ethers: 36
        Plasmalogens: 405
        PPI-1011: 3

Experts

1.	Ehrmantraut, Greg: 2 articles (12/2011 - 10/2011)
2.	Goodenowe, Dayan B: 2 articles (12/2011 - 10/2011)
3.	Khan, M Amin: 2 articles (12/2011 - 10/2011)
4.	Smith, Tara: 2 articles (12/2011 - 10/2011)
5.	Wood, Paul L: 2 articles (12/2011 - 10/2011)
6.	Bourque, Mélanie: 1 article (01/2018)
7.	Di Paolo, Thérèse: 1 article (01/2018)
8.	Grégoire, Laurent: 1 article (01/2018)
9.	Lane, Nina: 1 article (12/2011)
10.	Braverman, Nancy E: 1 article (10/2011)

Related Diseases

1.	Dyskinesias (Dyskinesia) 01/30/2018 - "We previously showed that a PlsEtn precursor PPI-1011 reduced already established L-DOPA-induced dyskinesias (LID) in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) lesioned monkeys as a PD model. " 01/30/2018 - "The plasmalogen precursor analog PPI-1011 reduces the development of L-DOPA-induced dyskinesias in de novo MPTP monkeys."
2.	Pelizaeus-Merzbacher Disease 10/18/2011 - "In vitro and in vivo plasmalogen replacement evaluations in rhizomelic chrondrodysplasia punctata and Pelizaeus-Merzbacher disease using PPI-1011, an ether lipid plasmalogen precursor."
3.	Alzheimer Disease (Alzheimer's Disease) 12/05/2011 - "Oral bioavailability of the ether lipid plasmalogen precursor, PPI-1011, in the rabbit: a new therapeutic strategy for Alzheimer's disease."

Related Drugs and Biologics

1.	Plasmalogens
2.	Lipids
3.	Ether (Diethyl Ether)
4.	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)
5.	Levodopa (L Dopa)