methylstat

selectively inhibits Jumonji C domain-containing histone demethylases

Also Known As:

4-(hydroxy-(4-((4-(((1-naphthalenylamino)-oxomethoxy)methyl)phenyl)methylamino)butyl)amino)-4-oxo-2-butenoic acid methyl ester

Networked: 4 relevant articles (0 outcomes, 2 trials/studies)

1.	Multiple Myeloma 01/01/2020 - "In this study, we aimed to determine synergistic apoptotic and cytotoxic effects of methylstat and bortezomib on U266 and ARH77 multiple myeloma (MM) cells. " 01/01/2020 - "Synergistic Apoptotic Effects of Bortezomib and Methylstat on Multiple Myeloma Cells."
2.	Infertility (Sterility) 09/25/2022 - "This study predicted two transcription factors, FOXO1, and CREB1, targeted by miRNAs that can be modulated by the repurposed drugs, BRD-K55473186, and methylstat, respectively, for the treatment of infertility due to endometriosis. "
3.	Endometriosis 09/25/2022 - "This study predicted two transcription factors, FOXO1, and CREB1, targeted by miRNAs that can be modulated by the repurposed drugs, BRD-K55473186, and methylstat, respectively, for the treatment of infertility due to endometriosis. "
4.	Neoplasms (Cancer) 01/01/2019 - "Here we provide an overview of this distinct DNA methylation pattern in mammals and plants, and propose that a methylstat, which is a cis-element responsive to both DNA methylation and active demethylation activities and controlling the transcriptional activity of a key DNA methylation regulator, can help to explain the enigmatic DNA methylation patterns in aging cells and cancer cells." 01/01/2023 - "Re-compaction of chromatin by methylstat, a histone demethylase inhibitor, resulted in reduced growth selectively in subcutaneously grown tumors derived from right-sided cancers. "

1.	MicroRNAs (MicroRNA)
2.	Transcription Factors (Transcription Factor)
3.	Bortezomib (Velcade)
4.	Histone Demethylases
5.	Elements
6.	Chromatin