bromosporine

BET inhibitor

Also Known As:

Carbamic acid, N-(3-methyl-6-(4-methyl-3-((methylsulfonyl)amino)phenyl)-1,2,4-triazolo(4,3-b)pyridazin-8-yl)-, ethyl ester; Ethyl (3-methyl-6-(4-methyl-3-((methylsulfonyl)amino)phenyl)(1,2,4)triazolo(4,3-b)pyridazin-8-yl)carbamate

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Carboxylic Acids: 973
  - Acyclic Acids
    - Carbamates: 945
      - bromosporine: 4
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Triazoles: 1533
      - bromosporine: 4
  - Pyridazines: 11
    - bromosporine: 4

Experts

1.	Cheng, Xueyuan: 1 article (01/2020)
2.	Huang, Zhong: 1 article (01/2020)
3.	Jin, Wei: 1 article (01/2020)
4.	Long, Di: 1 article (01/2020)
5.	Brennan, Paul: 1 article (10/2016)
6.	Dovey, Oliver: 1 article (10/2016)
7.	Fedorov, Oleg: 1 article (10/2016)
8.	Filippakopoulos, Panagis: 1 article (10/2016)
9.	Fujisawa, Takao: 1 article (10/2016)
10.	Gingras, Anne-Claude: 1 article (10/2016)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2022 - "Bromosporine (bromo) monotherapy produced significant anti-tumor effects against established melanoma cell lines and patient-derived xenografts (PDXs). " 01/01/2022 - "BPTF targeting with the bromodomain inhibitor bromosporine, alone or in combination with the PI3K pathway inhibitor gedatolisib, produced significant anti-tumor effects against TNBC cells in vitro and in vivo. " 01/01/2022 - "Combinatorial therapy involving bromosporine and cobimetinib (bromo/cobi) showed synergistic anti-tumor effects in multiple BRAFi-resistant PDX models. "
2.	Colorectal Neoplasms (Colorectal Cancer) 01/01/2020 - "BET inhibitor bromosporine enhances 5-FU effect in colorectal cancer cells."
3.	Melanoma (Melanoma, Malignant) 01/01/2022 - "Here, we develop a therapeutic strategy for melanoma using bromosporine, a bromodomain inhibitor. " 01/01/2022 - "Bromosporine (bromo) monotherapy produced significant anti-tumor effects against established melanoma cell lines and patient-derived xenografts (PDXs). "
4.	Leukemia 10/01/2016 - "Promiscuous targeting of bromodomains by bromosporine identifies BET proteins as master regulators of primary transcription response in leukemia."

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Fluorouracil (Carac)
3.	cobimetinib
4.	gedatolisib

Related Therapies and Procedures

1.	Therapeutics