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hernandonine

isolated from the root wood of Hernandia nymphaeifolia

Also Known As:

11H-(1,3)Benzodioxolo(6,5,4-de)-1,3-benzodioxolo(4,5-g)quinolin-11-one; 11H-Bis(1,3)benzodioxolo(6,5,4-de:4',5'-g)quinolin-11-one

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - hernandonine: 2

Experts

1.	Chen, Jih-Jung: 1 article (11/2019)
2.	Chen, Yen-Ting: 1 article (11/2019)
3.	Wang, Hsiang-Tsui: 1 article (11/2019)
4.	Chen, Si-Bao: 1 article (06/2002)
5.	Gao, Guang-Yao: 1 article (06/2002)
6.	Li, Ye-Shi: 1 article (06/2002)
7.	Xiao, Pei Gen: 1 article (06/2002)
8.	Yu, Shi-Chun: 1 article (06/2002)

Related Diseases

1.

Neoplasms (Cancer)

11/01/2019 - "IMPLICATIONS: Our findings position hernandonine as a potential, particular, and orally administered cancer treatment agent appropriate for use in investigational clinical trials."
06/01/2002 - "The new alkaloid 1 [IC 50 (GLC-82) 8.8 +/- 0.2 microM, IC 50 (HCT) 10.1 +/- 0.3 microM] and hernandonine ( 3) [IC 50 (GLC-82) 7.6 +/- 0.5 microM, IC 50 (HCT) 8.2 +/- 0.5 microM] exhibited cytotoxicity towards the cancer cell lines."
11/01/2019 - "Targeting RNA Polymerase I with Hernandonine Inhibits Ribosomal RNA Synthesis and Tumor Cell Growth."

Related Drugs and Biologics

1.	Ribosomal RNA
2.	RNA Polymerase I (Polymerase I, RNA)
3.	Alkaloids