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KR-67607

11beta-HSD1 inhibitor

Also Known As:

(E)-4-(2-(6-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-methyl-1,1-dioxido-1,2,6-thiadiazinan-2-yl)acetamido)adamantan-1-carboxamide

Networked: 2 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Alicyclic Hydrocarbons: 1
      - Cycloparaffins: 6
        Adamantane: 182
        KR-67607: 2
    - Bridged-Ring Compounds: 1
      - Adamantane: 182
        KR-67607: 2
- Sulfur Compounds: 278
  - Thiazines: 3
    - Thiadiazines: 4
      - KR-67607: 2
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Thiazines: 3
    - Thiadiazines: 4
      - KR-67607: 2

Experts

1.	Ahn, Jin Hee: 2 articles (05/2020 - 11/2019)
2.	Choi, Kyoung Jin: 2 articles (05/2020 - 11/2019)
3.	Jung, Won Hoon: 2 articles (05/2020 - 11/2019)
4.	Kang, Sein: 2 articles (05/2020 - 11/2019)
5.	Kim, Ki Young: 2 articles (05/2020 - 11/2019)
6.	Na, Yoon-Ju: 2 articles (05/2020 - 11/2019)
7.	Park, Sung Bum: 2 articles (05/2020 - 11/2019)
8.	Nam, Hye Jin: 1 article (11/2019)

Related Diseases

1.	Dry Eye Syndromes (Dry Eye Syndrome) 05/25/2020 - "A Novel Selective 11β-HSD1 Inhibitor, (E)-4-(2-(6-(2,6-Dichloro-4-(Trifluoromethyl)Phenyl)-4-Methyl-1,1-Dioxido-1,2,6-Thiadiazinan-2-yl)Acetamido)Adamantan-1-Carboxamide (KR-67607), Prevents BAC-Induced Dry Eye Syndrome." 05/25/2020 - "In this study, the protective effects and underlying mechanisms of topical (E)-4-(2-(6-(2,6-dichloro-4-(trifluoromethyl)phenyl)-4-methyl-1,1-dioxido-1,2,6-thiadiazinan-2-yl)acetamido)adamantan-1-carboxamide (KR-67607), a novel selective 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) inhibitor, were investigated in benzalkonium chloride (BAC)-induced dry eye syndrome. "
2.	Ischemia 11/01/2019 - "Antioxidation was the major protective pathway of KR-67607 against chemically-induced ischemia-reperfusion in TM cells and the glucocorticoid receptor (GR) was closely associated with this pathway. "
3.	Glaucoma 11/01/2019 - "Furthermore, KR-67607 reversed the elevation of intra-ocular pressure (IOP), suggesting that the TM structure maintained by KR-67607 prevented the excessive rise in IOP that exacerbates glaucoma. "

Related Drugs and Biologics

1.	Oxidoreductases (Dehydrogenase)
2.	Benzalkonium Compounds (Benzalkonium Chloride)
3.	Glucocorticoid Receptors (Glucocorticoid Receptor)