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IC87361

DNA-PK inhibitor

Also Known As:

5-Hydroxy-7-morpholin-4-yl-2-phenyl-chromen-4-one

Networked: 3 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - IC87361: 3
  - Oxazines: 9
    - Morpholines: 6
      - IC87361: 3
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - IC87361: 3

Experts

1.	Cheng, Gary J: 2 articles (12/2019 - 11/2019)
2.	Dickson, Benjamin D: 2 articles (12/2019 - 11/2019)
3.	Hay, Michael P: 2 articles (12/2019 - 11/2019)
4.	Hunter, Francis W: 2 articles (12/2019 - 11/2019)
5.	Lipert, Barbara: 2 articles (12/2019 - 11/2019)
6.	Wilson, William R: 2 articles (12/2019 - 11/2019)
7.	Wong, Way Wua: 2 articles (12/2019 - 11/2019)
8.	Lee, Tet Woo: 1 article (12/2019)
9.	Gu, Yongchuan: 1 article (11/2019)
10.	Jackson, Rosanna K: 1 article (11/2019)

Related Diseases

1.	Neoplasms (Cancer) 06/15/2005 - "Furthermore, LLC tumors treated with radiation and IC87361 showed tumor growth delay that was significantly greater than tumors treated with radiation alone (P < 0.01 for 3 Gy alone versus 3 Gy + IC87361). " 06/15/2005 - "IC87361 induced radiosensitization of tumor microvasculature in wild-type mice that resembled the radiosensitive phenotype of tumor vessels in SCID mice. " 06/15/2005 - "Radiosensitization by IC87361 was eliminated in SCID tumor vasculature, which lack functional DNA-PK. "
2.	Hypoxia (Hypoxemia) 12/01/2019 - "Radiosensitization by IC87361 and olaparib was significantly enhanced under acute anoxia and chronic hypoxia.Conclusions" 11/01/2019 - "Hypoxia-selective radiosensitisation by SN38023, a bioreductive prodrug of DNA-dependent protein kinase inhibitor IC87361." 12/01/2019 - ": The DNA-PK inhibitors KU57788 and IC87361 are more effective radiosensitizers than the PARP-1 inhibitors olaparib and veliparib at non-cytotoxic concentrations in HNSCC cell cultures and their activity is enhanced by SLFN11 and hypoxia." 11/01/2019 - "One-electron reduction of the prodrug by radiolysis of anoxic formate solutions, and by metabolic reduction in anoxic HCT116/POR cells that overexpress cytochrome P450 oxidoreductase (POR), generated IC87361 efficiently as assessed by LC-MS. SN38023 inhibited radiation-induced Ser2056 autophosphorylation of DNA-PK catalytic subunit and radiosensitised HCT116/POR and UT-SCC-54C cells selectively under anoxia. "
3.	Squamous Cell Carcinoma of Head and Neck 12/01/2019 - ": Two PARP1 inhibitors (olaparib, veliparib) and two DNA-PK inhibitors (KU57788, IC87361) were tested in 14 HNSCC cell lines and two non-tumorigenic lines (HEK-293 and WI-38/Va-13), with drug exposure for 6 or 24 h post-irradiation, using regrowth assays. " 12/01/2019 - ": The DNA-PK inhibitors KU57788 and IC87361 are more effective radiosensitizers than the PARP-1 inhibitors olaparib and veliparib at non-cytotoxic concentrations in HNSCC cell cultures and their activity is enhanced by SLFN11 and hypoxia."

Related Drugs and Biologics

1.	DNA (Deoxyribonucleic Acid)
2.	DNA-Activated Protein Kinase
3.	Prodrugs
4.	Oxidoreductases (Dehydrogenase)
5.	Cytochrome P-450 Enzyme System (Cytochrome P450)
6.	olaparib
7.	veliparib
8.	8- dibenzothiophen- 4- yl- 2- morpholin- 4- yl- chromen- 4- one
9.	formic acid (formate)