velsecorat

selective glucocorticoid receptor modulator

Also Known As:

3-(5-((1R,2S)-2-((2,2-Difluoropropanoyl)amino)-1-(2,3-dihydro-1,4-benzodioxin-6-yl)propoxy)-1H-indazol-1-yl)-N-((3R)-tetrahydro-3-furanyl)benzamide; AZD7594; Benzamide, 3-(5-((1R,2S)-2-((2,2-difluoro-1-oxopropyl)amino)-1-(2,3-dihydro-1,4-benzodioxin-6-yl)propoxy)-1H-indazol-1-yl)-N-((3R)-tetrahydro-3-furanyl)-

Networked: 5 relevant articles (2 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Aggarwal, Ajay: 3 articles (01/2022 - 01/2019)
2.	Chen, Yingxue: 3 articles (01/2022 - 01/2019)
3.	Tehler, Ulrika: 3 articles (01/2022 - 10/2017)
4.	Prothon, Susanne: 2 articles (01/2022 - 01/2019)
5.	Forsman, Henrik: 2 articles (02/2019 - 01/2019)
6.	Aurivillius, Magnus: 1 article (01/2022)
7.	Eriksson, Ulf G: 1 article (01/2022)
8.	Calzetta, Luigino: 1 article (01/2020)
9.	Cazzola, Mario: 1 article (01/2020)
10.	Pane, Gloria: 1 article (01/2020)

Related Diseases

1.	Asthma (Bronchial Asthma) 02/18/2019 - "We investigated the safety and efficacy of AZD7594 in asthma. " 02/18/2019 - "Two-week treatment with AZD7594 demonstrated a favorable risk-benefit profile in patients with mild to moderate asthma. " 02/18/2019 - "Efficacy and safety of AZD7594, an inhaled non-steroidal selective glucocorticoid receptor modulator, in patients with asthma: a phase 2a randomized, double blind, placebo-controlled crossover trial." 01/01/2019 - "AZD7594 is a non-steroidal, selective, glucocorticoid receptor modulator (SGRM), currently in development for the treatment of asthma and chronic obstructive pulmonary disease. " 01/01/2020 - "Several compounds are currently under pre-clinical development, but only three novel experimental GR agonists (GW870086X, AZD5423, AZD7594) seem to have some potential therapeutic relevance and have entered clinical trials for the treatment of asthma. "
2.	Edema (Dropsy) 10/26/2017 - "Further optimization of inhaled drug properties provided a second, equally potent, candidate, 15m (AZD7594), that demonstrated an improved therapeutic ratio over the benchmark inhaled corticosteroid 3 (fluticasone propionate) and prolonged the inhibition of lung edema, indicating potential for once-daily treatment."
3.	Chronic Obstructive Pulmonary Disease (COPD) 01/01/2019 - "AZD7594 is a non-steroidal, selective, glucocorticoid receptor modulator (SGRM), currently in development for the treatment of asthma and chronic obstructive pulmonary disease. "

Related Drugs and Biologics

1.	Adrenal Cortex Hormones (Corticosteroids)
2.	Fluticasone (Cutivate)
3.	Glucocorticoid Receptors (Glucocorticoid Receptor)
4.	2,2,2- trifluoro- N- (1- ((1- (4- fluorophenyl)- 1H- indazol- 5- yl)oxy)- 1- (3- methoxyphenyl)- 2- propanyl)acetamide
5.	GW870086X
6.	velsecorat