alicapistat

selective inhibitor of human calpains 1 and 2

Also Known As:

1-benzyl-N-(4-(cyclopropylamino)-3,4-dioxo-1-phenyl-2-butanyl)-5-oxo-D-prolinamide; 2-pyrrolidinecarboxamide, N-(3-(cyclopropylamino)-2,3-dioxo-1-(phenylmethyl)propyl)-5-oxo-1-(phenylmethyl)-, (2R)-; ABT-957

Networked: 2 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrrolidines: 115
    - alicapistat: 2

Experts

1.	Gaisina, Irina N: 1 article (12/2020)
2.	Jastaniah, Ammar: 1 article (12/2020)
3.	Knopp, Rachel C: 1 article (12/2020)
4.	Thatcher, Gregory R J: 1 article (12/2020)
5.	Goss, Sandra: 1 article (01/2019)
6.	Jin, Ziyi: 1 article (01/2019)
7.	Locke, Charles: 1 article (01/2019)
8.	Lon, Hoi-Kei: 1 article (01/2019)
9.	Mendonca, Nuno: 1 article (01/2019)
10.	Othman, Ahmed A: 1 article (01/2019)

Related Diseases

1.	Alzheimer Disease (Alzheimer's Disease) 01/01/2019 - "Pharmacokinetics, Safety, Tolerability, and Pharmacodynamics of Alicapistat, a Selective Inhibitor of Human Calpains 1 and 2 for the Treatment of Alzheimer Disease: An Overview of Phase 1 Studies." 01/01/2019 - "Alicapistat is an orally active selective inhibitor of calpain 1 and 2 whose overactivation has been linked to Alzheimer disease (AD). " 12/03/2020 - "Calpain inhibitors have been proposed as drug candidates for neurodegenerative disorders, with ABT-957 entering clinical trials for Alzheimer's disease and mild cognitive impairment. "
2.	Cognitive Dysfunction 12/03/2020 - "Calpain inhibitors have been proposed as drug candidates for neurodegenerative disorders, with ABT-957 entering clinical trials for Alzheimer's disease and mild cognitive impairment. "
3.	Neurodegenerative Diseases (Neurodegenerative Disease) 12/03/2020 - "Calpain inhibitors have been proposed as drug candidates for neurodegenerative disorders, with ABT-957 entering clinical trials for Alzheimer's disease and mild cognitive impairment. "

Related Drugs and Biologics

1.	calpain inhibitors
2.	Calpain