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N,N'-diacetyl-p-phenylenediamine

promotes phagocytosis by microglia, improving cognitive deficits associated with Alzheimer's disease in mouse model

Also Known As:

DAPPD

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Polyamines: 3918
    - Diamines: 518
      - Phenylenediamines: 6
        N,N'-diacetyl-p-phenylenediamine: 3
  - Aniline Compounds: 46
    - Phenylenediamines: 6
      - N,N'-diacetyl-p-phenylenediamine: 3

Experts

1.	Bae, Jae-Sung: 2 articles (01/2021 - 11/2019)
2.	Choi, Min-Koo: 2 articles (01/2021 - 11/2019)
3.	Jin, Hee Kyung: 2 articles (01/2021 - 11/2019)
4.	Kang, Juhye: 2 articles (01/2021 - 11/2019)
5.	Kim, Mingeun: 2 articles (01/2021 - 11/2019)
6.	Lee, Misun: 2 articles (01/2021 - 11/2019)
7.	Lim, Mi Hee: 2 articles (01/2021 - 11/2019)
8.	Nam, Geewoo: 2 articles (01/2021 - 11/2019)
9.	Park, Min Hee: 2 articles (01/2021 - 11/2019)
10.	Song, Im-Sook: 2 articles (01/2021 - 11/2019)

Related Diseases

1.	Alzheimer Disease (Alzheimer's Disease) 11/19/2019 - "N,N'-Diacetyl-p-phenylenediamine restores microglial phagocytosis and improves cognitive defects in Alzheimer's disease transgenic mice." 01/01/2021 - "Consequently, Glu-DAPPD exhibits in vivo efficacies in alleviating neuroinflammation, reducing amyloid-β aggregate accumulation, and improving cognitive function in Alzheimer's disease transgenic mice. " 11/19/2019 - "Based on our mechanistic investigations in vitro and in vivo, 1) the capability of DAPPD to restore microglial phagocytosis is responsible for diminishing the accumulation of amyloid-β (Aβ) species and significantly improving cognitive function in the brains of 2 types of Alzheimer's disease (AD) transgenic mice, and 2) the rectification of microglial function by DAPPD is a result of its ability to suppress the expression of NLRP3 inflammasome-associated proteins through its impact on the NF-κB pathway. "
2.	Neuroinflammatory Diseases 11/19/2019 - "Overall, our in vitro and in vivo investigations on efficacies and molecular-level mechanisms demonstrate the ability of DAPPD to regulate microglial function, suppress neuroinflammation, foster cerebral Aβ clearance, and attenuate cognitive deficits in AD transgenic mouse models. " 01/01/2021 - "Consequently, Glu-DAPPD exhibits in vivo efficacies in alleviating neuroinflammation, reducing amyloid-β aggregate accumulation, and improving cognitive function in Alzheimer's disease transgenic mice. "
3.	Lymphoma (Lymphomas) 09/19/2006 - "We investigated in vitro genotoxic properties of PPD, MAPPD and DAPPD in the Ames test, the micronucleus test (MNT) in human lymphocytes and the mouse lymphoma assay (Hprt locus, PPD only). "

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