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AER-271

aquaporin-4 inhibitor

Also Known As:

2-((3,5-Bis(trifluoromethyl) phenyl)carbamoyl)-4-chlorophenyl dihydrogen phosphate

Networked: 2 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Phenols: 677
        Chlorophenols: 95
        AER-271: 2
        Chlorobenzenes: 5
        Chlorophenols: 95
        AER-271: 2

Experts

1.	Farr, George W: 2 articles (01/2019 - 01/2019)
2.	McGuirk, Paul R: 2 articles (01/2019 - 01/2019)
3.	Pelletier, Marc F: 2 articles (01/2019 - 01/2019)
4.	Adams, Amielia G: 1 article (01/2019)
5.	Alexander, Henry: 1 article (01/2019)
6.	Beahm, Derek L: 1 article (01/2019)
7.	Boron, Walter F: 1 article (01/2019)
8.	Buch, Jasen M: 1 article (01/2019)
9.	Clark, Robert S B: 1 article (01/2019)
10.	Detzel, Joshua M: 1 article (01/2019)

Related Diseases

1.	Brain Edema (Cerebral Edema) 01/01/2019 - "Treatment with AER-271 ameliorated early cerebral edema measured at 3 h after CA vs vehicle treated rats. " 01/01/2019 - "The aquaporin-4 inhibitor AER-271 blocks acute cerebral edema and improves early outcome in a pediatric model of asphyxial cardiac arrest." 01/01/2019 - "AER-270 and a prodrug with enhanced solubility, AER-271 2-{[3,5-Bis(trifluoromethyl) phenyl]carbamoyl}-4-chlorophenyl dihydrogen phosphate, improved neurological outcome and reduced swelling in two models of CNS injury complicated by cerebral edema: water intoxication and ischemic stroke modeled by middle cerebral artery occlusion."
2.	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 01/01/2019 - "AER-270 and a prodrug with enhanced solubility, AER-271 2-{[3,5-Bis(trifluoromethyl) phenyl]carbamoyl}-4-chlorophenyl dihydrogen phosphate, improved neurological outcome and reduced swelling in two models of CNS injury complicated by cerebral edema: water intoxication and ischemic stroke modeled by middle cerebral artery occlusion."
3.	Water Intoxication 01/01/2019 - "AER-270 and a prodrug with enhanced solubility, AER-271 2-{[3,5-Bis(trifluoromethyl) phenyl]carbamoyl}-4-chlorophenyl dihydrogen phosphate, improved neurological outcome and reduced swelling in two models of CNS injury complicated by cerebral edema: water intoxication and ischemic stroke modeled by middle cerebral artery occlusion."
4.	Ischemic Stroke 01/01/2019 - "AER-270 and a prodrug with enhanced solubility, AER-271 2-{[3,5-Bis(trifluoromethyl) phenyl]carbamoyl}-4-chlorophenyl dihydrogen phosphate, improved neurological outcome and reduced swelling in two models of CNS injury complicated by cerebral edema: water intoxication and ischemic stroke modeled by middle cerebral artery occlusion."
5.	Heart Arrest (Cardiac Arrest) 01/01/2019 - "The aquaporin-4 inhibitor AER-271 blocks acute cerebral edema and improves early outcome in a pediatric model of asphyxial cardiac arrest."

Related Drugs and Biologics

1.	Prodrugs
2.	Phosphates (Orthophosphate)
3.	salicylhydroxamic acid (SHAM)